6-mercaptoindolo[1,2-c]quinazoline | 382140-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-mercaptoindolo[1,2-c]quinazoline
• 英文别名: 5H-indolo[1,2-c]quinazoline-6-thione
• CAS: 382140-31-0
• 化学式: C₁₅H₁₀N₂S
• 分子量: 250.324
• InChiKey: WYRLCMCQXVIPND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-mercaptoindolo[1,2-c]quinazoline 在 sodium hydride 、 甲烷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.83h， 生成 5a,14b,15-triazabenzo[a]indeno[1,2-c]anthracen-5-one
  参考文献：
  名称：

  Efficient modified von Niementowski synthesis of novel derivatives of 5a,14b,15-triazabenzo[a]indeno[1,2-c]anthracen-5-one from indolo[1,2-c]quinazoline

  摘要：

  Starting from 2-(2-aminophenyl)indole novel triazabenzo[a]indeno[1,2-c]anthracen-5-ones could be reached in three steps through a modified von Niementowski reaction, which involves condensation of anthranilic acids with an S-alkylated 6-mercaptoindolo[1,2-c]quinazoline. Microwave irradiation in dry media was used in order to improve reactions where conventional heating was limited. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01364-8
• 作为产物：
  描述：

  二硫化碳 、 2-(2-氨基苯基)吲哚 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以92%的产率得到6-mercaptoindolo[1,2-c]quinazoline
  参考文献：
  名称：

  Efficient modified von Niementowski synthesis of novel derivatives of 5a,14b,15-triazabenzo[a]indeno[1,2-c]anthracen-5-one from indolo[1,2-c]quinazoline

  摘要：

  Starting from 2-(2-aminophenyl)indole novel triazabenzo[a]indeno[1,2-c]anthracen-5-ones could be reached in three steps through a modified von Niementowski reaction, which involves condensation of anthranilic acids with an S-alkylated 6-mercaptoindolo[1,2-c]quinazoline. Microwave irradiation in dry media was used in order to improve reactions where conventional heating was limited. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01364-8

文献信息

• Efficient modified von Niementowski synthesis of novel derivatives of 5a,14b,15-triazabenzo[a]indeno[1,2-c]anthracen-5-one from indolo[1,2-c]quinazoline
  作者：Lisianne Domon、Catherine Le Coeur、Axelle Grelard、Valérie Thiéry、Thierry Besson

  DOI：10.1016/s0040-4039(01)01364-8

  日期：2001.9

  Starting from 2-(2-aminophenyl)indole novel triazabenzo[a]indeno[1,2-c]anthracen-5-ones could be reached in three steps through a modified von Niementowski reaction, which involves condensation of anthranilic acids with an S-alkylated 6-mercaptoindolo[1,2-c]quinazoline. Microwave irradiation in dry media was used in order to improve reactions where conventional heating was limited. (C) 2001 Published by Elsevier Science Ltd.