(1S)-1-[(2S)-3-ethyl-3,4-dihydro-2H-thiopyran-2-yl]-2-phenylethanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S)-1-[(2S)-3-ethyl-3,4-dihydro-2H-thiopyran-2-yl]-2-phenylethanamine
• 化学式: C₁₅H₂₁NS
• 分子量: 247.4
• InChiKey: NZLBIPOLIJUDGY-FGRDXJNISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] HYDROPHILIC SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF<br/>[FR] LIEURS AUTO-IMMOLABLES HYDROPHILES ET CONJUGUÉS DE CEUX-CI
  申请人：BIOLLIANCE C V

  公开号：WO2014100762A1

  公开（公告）日：2014-06-26

  The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.