Furan;1-(2-hydroxyethyl)pyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Furan;1-(2-hydroxyethyl)pyrrole-2,5-dione
• 英文别名: furan;1-(2-hydroxyethyl)pyrrole-2,5-dione
• 化学式: C10H11NO4
• 分子量: 209.2
• InChiKey: LSJPUIUMYPYWIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.18
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Modified Polyaryletherketone Polymer (Paek) and Process To Obtain It
  申请人：UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA

  公开号：US20160053042A1

  公开（公告）日：2016-02-25

  The present invention relates to a modified polyaryletherketone polymer (PAEK) with chemically modified surfaces with azides, alkynes, thiols, maleimides, sulfonylazides or thio acids, suitable for “click” reactions and to a process to obtain it. It also relates to the conjugated biomaterials derived thereof, PAEK type materials with surfaces modified with a RGD (Arg-Gly-Asp) and/or OGP 10-14 (Tyr-Gly-Phe-Gly-Gly) peptidomimetics and to a process to obtain it. These materials are particularly useful for manufacturing medical devices. Finally, the present invention also relates to a fluorescent PAEK material.

  本发明涉及一种经过化学修饰的聚芳醚酮聚合物（PAEK），其表面经过氮化物、炔烃、硫醇、马来酰亚胺、磺酰氮化物或硫酸等化学修饰，适用于“点击”反应，并提供了制备该聚合物的方法。本发明还涉及由此衍生的共轭生物材料，PAEK类型的材料，其表面修饰有RGD（Arg-Gly-Asp）和/或OGP10-14（Tyr-Gly-Phe-Gly-Gly）肽类模拟物，并提供了制备该材料的方法。这些材料特别适用于制造医疗器械。最后，本发明还涉及一种荧光PAEK材料。
• Modified polyaryletherketone polymer (PAEK) and process to obtain it
  申请人：Universidad Del Pais Vasco-Euskal Herriko Unibertsitatea

  公开号：EP2749300A1

  公开（公告）日：2014-07-02

  The present invention relates to a modified polyaryletherketone polymer (PAEK) with chemically modified surfaces with azides, alkynes, thiols, maleimides, sulfonylazides or thio acids, suitable for "click" reactions and to a process to obtain it. It also relates to the conjugated biomaterials derived thereof, PAEK type materials with surfaces modified with a RGD (Arg- Gly-Asp) and/or OGP10-14 (Tyr-Gly-Phe-Gly-Gly) peptidomimetics and to a process to obtain it. These materials are particularly useful for manufacturing medical devices. Finally, the present invention also relates to a fluorescent PAEK material.

  本发明涉及一种改性聚芳醚酮聚合物（PAEK），其表面经叠氮化物、炔烃、硫醇、马来酰亚胺、磺酰基氮化物或硫代酸化学改性，适用于 "点击 "反应，还涉及一种获得该聚合物的工艺。它还涉及由其衍生的共轭生物材料，即表面用 RGD（Arg-Gly-Asp）和/或 OGP10-14（Tyr-Gly-Phe-Gly-Gly）拟肽修饰的 PAEK 型材料，以及获得这种材料的工艺。这些材料特别适用于制造医疗器械。最后，本发明还涉及一种荧光 PAEK 材料。