(E)-N-tert-butyl-2,2-dimethyl-4-phenylbut-3-enamide | 130446-71-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-tert-butyl-2,2-dimethyl-4-phenylbut-3-enamide
• CAS: 130446-71-8
• 化学式: C₁₆H₂₃NO
• 分子量: 245.365
• InChiKey: ZPZGKVKAZVNQBC-VAWYXSNFSA-N

物化性质

• 沸点：
  406.0±34.0 °C(Predicted)
• 密度：
  0.973±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (PhCHCHC(t-Bu)CN-t-Bu)-tricarbonyliron(0) 、 甲基锂 生成 (E)-N-tert-butyl-2,2-dimethyl-4-phenylbut-3-enamide
  参考文献：
  名称：

  HILL, LAWRENCE;RICHARDS, CHRISTOPHER J.;THOMAS, SUSAN E., J. CHEM. SOC. CHEM. COMMUN.,(1990) N6, C. 1085-1086

  摘要：

  DOI：

文献信息

• Nucleophilic addition to vinylketene- and vinylketenimine (allenylideneamine)tricarbonyliron(0) complexes
  作者：Lawrence Hill、Christopher J. Richards、Susan E. Thomas

  DOI：10.1039/c39900001085

  日期：——

  Nucleophiles add to C-1 of (vinylketene)tricarbonyliron(0) complexes to give β,γ-unsaturated carbonyl derivatives, whereas nucleophilic attack on a (vinylketenimine)tricarbonyliron(0) analogue occurs at C-2 and leads, after an oxidative work-up, to β,γ-unsaturated amides containing an a quaternary centre.

  亲核试剂添加到（乙烯基乙烯酮）三羰基铁（0）配合物的C-1中，生成β，γ-不饱和羰基衍生物，而对（乙烯基乙烯亚胺）三羰基铁（0）类似物的亲核攻击发生在C-2处，并在氧化作用后产生到含有一个季中心的β，γ-不饱和酰胺。
• Nucleophilic addition to vinylketenimine complexes. The asymmetric synthesis of carbon quaternary centres
  作者：Christopher J. Richards、Susan E. Thomas

  DOI：10.1016/s0957-4166(00)82321-6

  日期：1992.1

  Addition of alkyl-lithium reagents to (vinylketenimine)tricarbonyliron(0) complexes generates compounds containing carbon quaternary centres. The major products from these reactions are either amides or aldehydes depending upon the conditions employed. Diastereomerically pure vinylketenimine complexes 7 and 8 of known absolute configuration were synthesised from (S)-alpha-methylbenzylisonitrile 6 (96% e.e.) and the (vinylketene)tricarbonyliron(0) complex 2. The addition of alkyl-lithium reagents to 7 and 8 occurred exclusively exo to the Fe(CO)3 group and the resulting compounds, which contained chiral quaternary centres, were found to be of high optical purity.