1-aminopropan-2-ol;1H-pyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 1-aminopropan-2-ol;1H-pyrrole
• 化学式: C7H14N2O
• 分子量: 142.2
• InChiKey: RDIXDCJOWMLZOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.34
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  62
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR THE PREPARATION OF MACITENTAN AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE MACITENTAN ET D'INTERMÉDIAIRES DE CE DERNIER
  申请人：MEGAFINE PHARMA (P) LTD

  公开号：WO2016203489A1

  公开（公告）日：2016-12-22

  The present invention relates to an improved process for preparation of Macitentan and intermediates thereof. The present invention also relates to a novel ammonium salt of Macitentan. The present invention further relates to a process for the preparation of amorphous Macitentan.

  本发明涉及一种改进的制备马西替坦及其中间体的方法。本发明还涉及马西替坦的一种新型铵盐。本发明还涉及一种制备非晶态马西替坦的方法。
• [EN] A PROCESS FOR PREPARATION OF TICAGRELOR AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE TICAGRELOR ET DE SES INTERMÉDIAIRES
  申请人：MEGAFINE PHARMA P LTD

  公开号：WO2014102830A1

  公开（公告）日：2014-07-03

  An improved process for the preparation of ticagrelor and its intermediates thereof; wherein the said process substantially eliminates the potential impurities.

  一种改进的制备替卡格雷和其中间体的工艺；其中该工艺基本消除了潜在的杂质。
• [EN] AN IMPROVED PROCESS FOR PREPARATION OF TICAGRELOR AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DU TICAGRELOR ET INTERMÉDIAIRES CORRESPONDANTS
  申请人：STRIDES SHASUN LTD

  公开号：WO2016128996A2

  公开（公告）日：2016-08-18

  An improved, industrially viable, environment friendly and economically significant process for preparation of Ticagrelor is disclosed alongwith novel intermediates for the Ticagrelor synthesis.
• [EN] PROCESS FOR THE PREPARATION OF SELEXIPAG AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE SÉLEXIPAG ET INTERMÉDIAIRES DE CE DERNIER
  申请人：MEGAFINE PHARMA (P) LTD

  公开号：WO2017042828A2

  公开（公告）日：2017-03-16

  The present invention provides processes for the preparation of Selexipag compound of formula (1). The present invention also provides processes for the preparation of 4-[(5,6-diphenyl-pyrazin-2-yl)-isopropyl -amino]-butan-1-ol (2), and 4-isopropylamino-butan-1-ol of formula (3), which are intermediates for the synthesis of Selexipag (1 ).