1H-imidazole;2-methylpyridine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1H-imidazole;2-methylpyridine-3-carboxylic acid
• 化学式: C10H11N3O2
• 分子量: 205.21
• InChiKey: YIAQYVXJOPEWOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Post-transcriptionally chemically modified double strand RNAs
  申请人：nanoSUR LLC

  公开号：US10131911B2

  公开（公告）日：2018-11-20

  Described are post transcriptionally chemically modified double strand RNAs (MdsRNAs) having more than 30 base pairs. The MdsRNAs inhibit gene expression in target organisms. Also described are methods of making and using MdsRNAs.

  所描述的是转录后化学修饰的双链 RNA（MdsRNA），其碱基对超过 30 个。这些 MdsRNAs 可抑制目标生物的基因表达。还描述了制造和使用 MdsRNAs 的方法。
• Low sequence bias single-stranded DNA ligation
  申请人：The Penn State Research Foundation

  公开号：US10640828B2

  公开（公告）日：2020-05-05

  The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3′-overhang region such that the overhang is able to hybridize to nucleotides present in the 3′ end of the acceptor molecule.

  本发明提供了用于连接单链核酸的组合物和方法，其中连接基于受体分子与供体分子的快速、高效和低序列偏差杂交。在一个实施方案中，供体分子的结构包括茎环分子内核苷酸碱基配对（即发夹）和 3′-悬垂区，使悬垂区能够与受体分子 3′端存在的核苷酸杂交。
• Method of producing an aptamer and uses thereof
  申请人：City University of Hong Kong

  公开号：US11326169B2

  公开（公告）日：2022-05-10

  A method of producing an aptamer selectively binding a non-canonical structure of a target nucleic acid molecule includes the steps of: incubating a plurality of nucleic acid sequences with an enantiomer of the non-canonical structure under suitable conditions to obtain one or more candidate nucleic acid sequences binding to the enantiomer of the non-canonical structure, purifying and amplifying the one or more candidate nucleic acid sequences; repeating said incubating, purifying and amplifying steps for a predetermined number of cycles under different conditions; and producing an enantiomer for selected amplified candidate nucleic acid sequence to obtain the aptamer capable of selectively binding the non-canonical structure of the target nucleic acid molecule. An aptamer selectively binding to a non-canonical structure of a nucleic acid molecule or its enantiomer, the aptamer comprising a sequence of SEQ ID NO: 11; as well as uses of the aptamer or its enantiomer.

  一种生产选择性结合目标核酸分子非典型结构的适配体的方法包括以下步骤：在适当条件下将多个核酸序列与非典型结构的对映体孵育，以获得一个或多个与非典型结构的对映体结合的候选核酸序列，纯化和扩增一个或多个候选核酸序列；在不同条件下重复上述孵育、纯化和扩增步骤预定次数的循环；以及为选定的扩增候选核酸序列生产对映体，以获得能够选择性结合目标核酸分子非典型结构的适配体。一种可选择性结合核酸分子非经典结构的适配体或其对映体，该适配体包括 SEQ ID NO: 11 的序列；以及该适配体或其对映体的用途。
• COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES
  申请人：Arrakis Therapeutics, Inc.

  公开号：EP3411080A2

  公开（公告）日：2018-12-12
• POST-TRANSCRIPTIONALLY CHEMICALLY MODIFIED DOUBLE STRAND RNAS
  申请人：Nanosur LLC

  公开号：EP3535274A2

  公开（公告）日：2019-09-11