[Amino-[3-(2,5-dioxopyrrol-1-yl)propanoyl]amino] 2,2,2-trifluoroacetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: [Amino-[3-(2,5-dioxopyrrol-1-yl)propanoyl]amino] 2,2,2-trifluoroacetate
• 英文别名: [amino-[3-(2,5-dioxopyrrol-1-yl)propanoyl]amino] 2,2,2-trifluoroacetate
• 化学式: C₉H₈F₃N₃O₅
• 分子量: 295.17
• InChiKey: VBZGJOOYQFLVFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• SURFACE BINDING OF NANOPARTICLE BASED DRUG DELIVERY TO TISSUE
  申请人：Massachusetts Institute of Technology

  公开号：US20140193508A1

  公开（公告）日：2014-07-10

  Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury.

  提供微粒和纳米粒子及其组合物。这些微粒和纳米粒子及其组合物可用于治疗肌肉骨骼疾病，如骨关节炎和损伤。
• Surface binding of nanoparticle based drug delivery to tissue
  申请人：Massachusetts Institute of Technology

  公开号：US10226427B2

  公开（公告）日：2019-03-12

  Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury such as trauma.

  提供了微粒子和纳米粒子及其组合物。这些微颗粒和纳米颗粒及其组合物可用于治疗肌肉骨骼疾病，如骨关节炎和创伤等损伤。
• Microfluidic platform for multiplexed detection in single cells and methods thereof
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US10731205B2

  公开（公告）日：2020-08-04

  The present invention relates to a microfluidic device and platform configured to conduct multiplexed analysis within the device. In particular, the device allows multiple targets to be detected on a single-cell level. Also provided are methods of performing multiplexed analyses to detect one or more target nucleic acids, proteins, and post-translational modifications.

  本发明涉及一种微流控装置和平台，可在该装置内进行多重分析。特别是，该装置允许在单细胞水平上检测多个目标。本发明还提供了进行多重分析以检测一种或多种靶核酸、蛋白质和翻译后修饰的方法。
• Detection of active and latent infections with microfluidic devices and systems thereof
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US10786811B1

  公开（公告）日：2020-09-29

  The present invention relates to methods of detecting one or more targets of interest in a sample. In one instance, the target can be correlated to an active infection (e.g., by a virus and/or a bacterium). Methods can include treating the sample with a dissociation agent, thereby releasing the target of interest for more accurate detection (e.g., by use of a sedimentation-based centrifugal microfluidic devices). Also described herein are microfluidic devices and systems for use with a dissociation agent.

  本发明涉及检测样本中一个或多个相关目标的方法。在一种情况下，目标可与活动感染（如病毒和/或细菌感染）相关。方法可包括用解离剂处理样品，从而释放出感兴趣的目标物，以便进行更准确的检测（例如，通过使用基于沉降的离心微流控装置）。本文还描述了与解离剂一起使用的微流控装置和系统。
• Expanded pore particles and delivery methods thereof
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US10933027B1

  公开（公告）日：2021-03-02

  The present invention relates to a construct including a porous core, a cargo, and a spacer disposed between the core and the cargo. In some examples, the construct further includes an outer layer composed of a lipid, a polymer, or a combination thereof. Methods of making and employing such constructs are also described herein.

  本发明涉及一种构造物，包括多孔内核、货物以及设置在内核和货物之间的间隔物。在某些实例中，该结构体还包括由脂质、聚合物或其组合构成的外层。本文还描述了制造和使用这种构造物的方法。