2-Methoxy-6-(1,3,5-trimethylpyrazol-4-yl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Methoxy-6-(1,3,5-trimethylpyrazol-4-yl)pyridine
• 英文别名: 2-methoxy-6-(1,3,5-trimethylpyrazol-4-yl)pyridine
• 化学式: C₁₂H₁₅N₃O
• 分子量: 217.27
• InChiKey: MQHBUYYPMDQAHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
  申请人：Ruf Sven

  公开号：US20140194445A1

  公开（公告）日：2014-07-10

  The present invention relates to compounds of the formula I, wherein A, D, E, L, G, R 10 , R 30 , R 40 , R 50 and R 60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
• US9120783B2
  申请人：——

  公开号：US9120783B2

  公开（公告）日：2015-09-01