2-Methoxy-6-(1-methylpyrazol-4-yl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Methoxy-6-(1-methylpyrazol-4-yl)pyridine
• 英文别名: 2-methoxy-6-(1-methylpyrazol-4-yl)pyridine
• 化学式: C₁₀H₁₁N₃O
• 分子量: 189.21
• InChiKey: MLUVVHZETSWGLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL PYRAZOLE DERIVATIVE
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：US20150133448A1

  公开（公告）日：2015-05-14

  It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g. mental disorder and neurodegenerative disorder). The present invention provides: compounds having PDE10 inhibitory effect, in particular, compounds having a 4-heteroarylpyrazole-5-carboxylic acid amide structure represented by the following formula (I), or their pharmaceutically acceptable salts, or their solvates; pharmaceutical compositions comprising, as active ingredients, the compounds, or their pharmaceutically acceptable salts, or their solvates; and medical use of the compounds, or their pharmaceutically acceptable salts, or their solvates.

  旨在开发一种药物组合物，用于预防和/或治疗与PDE10有关的各种疾病（例如精神障碍和神经退行性疾病）的药剂。本发明提供：具有PDE10抑制效果的化合物，特别是具有以下式（I）所代表的4-杂环芘唑-5-羧酸酰胺结构的化合物，或其药学上可接受的盐或其溶剂；包含上述化合物或其药学上可接受的盐或其溶剂作为活性成分的制药组合物；以及上述化合物或其药学上可接受的盐或其溶剂的医药用途。
• SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
  申请人：Ruf Sven

  公开号：US20140194445A1

  公开（公告）日：2014-07-10

  The present invention relates to compounds of the formula I, wherein A, D, E, L, G, R 10 , R 30 , R 40 , R 50 and R 60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
• US9120783B2
  申请人：——

  公开号：US9120783B2

  公开（公告）日：2015-09-01
• US9440970B2
  申请人：——

  公开号：US9440970B2

  公开（公告）日：2016-09-13