N'-hydroxy-N-[4-[[[3-(3-oxa-25-aza-9-azoniaheptacyclo[18.8.1.15,9.02,18.04,16.025,29.014,30]triaconta-1(29),2(18),4,9(30),14,16,19-heptaen-17-yl)benzoyl]amino]methyl]phenyl]octanediamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-hydroxy-N-[4-[[[3-(3-oxa-25-aza-9-azoniaheptacyclo[18.8.1.15,9.02,18.04,16.025,29.014,30]triaconta-1(29),2(18),4,9(30),14,16,19-heptaen-17-yl)benzoyl]amino]methyl]phenyl]octanediamide
• 化学式: C49H56N5O5+
• 分子量: 795.0
• InChiKey: GIIWUAMEXHRCTO-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  59
• 可旋转键数：
  12
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• RECOGNITION OF CELLULAR TARGET BINDING BY A BIOACTIVE AGENT USING INTRACELLULAR BIOLUMINESCENCE RESONANCE ENERGY TRANSFER
  申请人：Promega Corporation

  公开号：US20140194307A1

  公开（公告）日：2014-07-10

  The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, or portions, components, or subunits of bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.

  本发明提供了一种检测和分析生物活性物质与细胞靶标内部结合的组合物和方法。具体而言，提供了生物活性物质与荧光染料相结合，细胞靶标与生物发光报告基因融合，或生物发光报告基因的部分、组分或亚单位，以及检测和分析生物活性物质与细胞靶标交互作用的方法。
• Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer
  申请人：Promega Corporation

  公开号：US10024862B2

  公开（公告）日：2018-07-17

  The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, or portions, components, or subunits of bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.

  本发明提供了用于检测和分析生物活性剂与细胞靶标的胞内结合的组合物和方法。特别是，本发明提供了与荧光团连接的生物活性剂、与生物发光报告体融合的细胞靶标或生物发光报告体的部分、组分或亚基，以及检测和分析生物活性剂与细胞靶标相互作用的方法。