3-Chlorosulfonyl-5-methylsulfanylbenzoyl chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Chlorosulfonyl-5-methylsulfanylbenzoyl chloride
• 英文别名: 3-chlorosulfonyl-5-methylsulfanylbenzoyl chloride
• 化学式: C₈H₆Cl₂O₃S₂
• 分子量: 285.2
• InChiKey: UTTAMKIWCZXNFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  84.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US20140194416A1

  公开（公告）日：2014-07-10

  The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

  该发明涉及一种在生理条件下捐赠亚硝酰（HNO）的N-羟基磺酰胺衍生物，其可用于治疗和/或预防对亚硝酰治疗有反应的疾病或病情的发生和/或发展，包括心力衰竭和缺血/再灌注损伤。新型的N-羟基磺酰胺衍生物在生理条件下以受控速率释放HNO，HNO释放速率通过改变N-羟基磺酰胺衍生物上的功能基团的性质和位置来调节。