(5Z)-5-[[5-(2-methoxy-5-nitrophenyl)furan-2-yl]methylidene]-3-phenylimidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5Z)-5-[[5-(2-methoxy-5-nitrophenyl)furan-2-yl]methylidene]-3-phenylimidazolidine-2,4-dione
• 化学式: C21H15N3O6
• 分子量: 405.4
• InChiKey: UHCKKBZHZRQNBD-ATVHPVEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Methods of modulating neurotrophin-mediated activity
  申请人：Ross M. Gregory

  公开号：US20050282840A1

  公开（公告）日：2005-12-22

  Disclosed are compositions which modulate the interaction of nerve growth factor and brain-derived neurotrophic factor with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.

  本发明揭示了一种调节神经生长因子和脑源性神经营养因子与神经营养受体相互作用的组合物。还揭示了使用该发明的组合物的方法，包括给药方法。
• EP1718308A4
  申请人：——

  公开号：EP1718308A4

  公开（公告）日：2007-07-18
• METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY
  申请人：PainCeptor Pharma Corp.

  公开号：EP1718308A2

  公开（公告）日：2006-11-08
• [EN] OPTICAL FILM, OPTICAL COMPENSATION SHEET, POLARIZNG PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE<br/>[FR] FILM OPTIQUE, FEUILLE DE COMPENSATION OPTIQUE, PLAQUE POLARISANTE ET DISPOSITIF D'AFFICHAGE À CRISTAUX LIQUIDES
  申请人：FUJI PHOTO FILM CO LTD

  公开号：WO2005081642A2

  公开（公告）日：2005-09-09

  An optical film, which contains a cellulose acylate, at least one compound of formula (I) in an amount of 0.01 to 20 mass parts, and at least one cyclic compound having at least three substituents in an amount of 0.01 to 20 mass parts, to 100 mass parts of the cellulose acylate: Formula (I) wherein R1 to R7, R9 and R10 each independently is a hydrogen atom or a substituent; at least one of R1 to R5 is an electron-donating group; R8 is a hydrogen atom, an alkyl group, an alkenyl group, an alkinyl group, an aryl group, an alkoxy group, an aryloxy group, an alkoxycarbonyl group, an acylamino group, an alkylcarbonyloxy group, a cyano group, or a halogen atom; and an optical compensation sheet, a polarizing plate, and a liquid crystal display device, each of which uses the optical film.
• [EN] METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY<br/>[FR] PROCÉDÉ DE MODULATION DE L'ACTIVITÉ PROVOQUÉE PAR L'INTERMÉDIAIRE DE LA NEUROTROPHINE
  申请人：PAINCEPTOR PHARMA CORP

  公开号：WO2005076695A2

  公开（公告）日：2005-08-25

  Disclosed are compositions which modulate the interaction of nerve growth factor and brain-derived neurotrophic factor with neurotrophic receptors, comprising contacting cells expressing a neurotrophin receptor with an effective amount of a compound of Formulas 1-6. Also disclosed are methods of using the compositions of the invention for the treatment of pain, inflammatory disorder and neurological disorder in subject in need.