2-Acetamido-N-(2,6-dioxopiperidin-3-yl)-6-nitrobenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Acetamido-N-(2,6-dioxopiperidin-3-yl)-6-nitrobenzamide
• 英文别名: 2-acetamido-N-(2,6-dioxopiperidin-3-yl)-6-nitrobenzamide
• 化学式: C14H14N4O6
• 分子量: 334.28
• InChiKey: FCUYOIKMCLZJRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  150
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES<br/>[FR] DÉRIVÉS DE 3-(5-SUBSTITUTÉ-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTÉRO-PIPÉRIDINE-2,6-DIONE
  申请人：DEUTERX LLC

  公开号：WO2014110558A1

  公开（公告）日：2014-07-17

  The invention provides 3 -deuterium-enriched 3-(5-substituted-4-oxoquinazolin-3(4H)- yl)- piperidine-2,6-diones, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treatment using the same, such as in the treatment of cancer, an immune-related disease, or an inflammatory disease.

  该发明提供了3-氘富集的3-(5-取代-4-氧喹唑啉-3(4H)-基)-哌啶-2,6-二酮，其氘代衍生物，其立体异构体，其药用盐形式，以及使用它们进行治疗的方法，例如在癌症治疗、免疫相关疾病或炎症性疾病的治疗中。
• 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
  申请人：DeuteRx, LLC

  公开号：US20140228382A1

  公开（公告）日：2014-08-14

  The invention provides 3-deuterium-enriched 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-piperidine-2,6-diones, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treatment using the same, such as in the treatment of cancer, an immune-related disease, or an inflammatory disease.

  该发明提供了3-氘富集的3-(5-取代-4-氧代喹唑啉-3(4H)-基)-哌啶-2,6-二酮，其氘代衍生物，其立体异构体，其药物可接受的盐形式，以及使用它们的治疗方法，例如用于治疗癌症、免疫相关疾病或炎症性疾病。
• 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same
  申请人：DeuteRx, LLC

  公开号：US10202316B2

  公开（公告）日：2019-02-12

  The invention provides 3-deuterium-enriched 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-piperidine-2,6-diones, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treatment using the same, such as in the treatment of cancer, an immune-related disease, or an inflammatory disease.

  本发明提供了富含3-氘代的3-(5-取代-4-氧代喹唑啉-3(4H)-基)-哌啶-2,6-二酮、其氘代衍生物、其立体异构体、其药学上可接受的盐形式，以及使用这些物质的治疗方法，例如治疗癌症、免疫相关疾病或炎症性疾病的方法。
• 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES
  申请人：Deuterx, LLC

  公开号：EP2943201A1

  公开（公告）日：2015-11-18
• US9540340B2
  申请人：——

  公开号：US9540340B2

  公开（公告）日：2017-01-10