2-[4-Bromo-3-[3-[(dimethylamino)methyl]-2,4-dihydroxyphenyl]phenoxy]acetaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-Bromo-3-[3-[(dimethylamino)methyl]-2,4-dihydroxyphenyl]phenoxy]acetaldehyde
• 英文别名: 2-[4-bromo-3-[3-[(dimethylamino)methyl]-2,4-dihydroxyphenyl]phenoxy]acetaldehyde
• 化学式: C₁₇H₁₈BrNO₄
• 分子量: 380.2
• InChiKey: DAFALXAZJPSOCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Activation or reactivation of ache
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US10125117B2

  公开（公告）日：2018-11-13

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.

  本文公开了一种利用本公开的化合物激活或逆转乙酰胆碱酯酶（AChE）或丁酰胆碱酯酶（BuchE）失活的体外或体内方法。还公开了一种使用此类化合物治疗暴露于神经毒剂的受试者的方法。还公开了一种使用此类化合物治疗有机磷中毒的方法。还公开了一种使用此类化合物调节受试者神经元信号传导和传递的方法。
• ACTIVATION OR REACTIVATION OF ACHE
  申请人：Stojanovic Milan

  公开号：US20160031854A1

  公开（公告）日：2016-02-04

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
• [EN] ACTIVATION OR REACTIVATION OF ACHE<br/>[FR] ACTIVATION OU RÉACTIVATION DE L'ACÉTYLCHOLINESTÉRASE
  申请人：UNIV COLUMBIA

  公开号：WO2014113495A1

  公开（公告）日：2014-07-24

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
• [EN] ACTIVATION OR REACTIVATION OF ACHE<br/>[FR] ACTIVATION OU RÉACTIVATION DE L'ACHE
  申请人：UNIV COLUMBIA

  公开号：WO2014210168A1

  公开（公告）日：2014-12-31

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.