2-(acetyloxy)-4-[(5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene)methyl]phenyl acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2-(acetyloxy)-4-[(5-oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene)methyl]phenyl acetate
• 英文别名: [2-acetyloxy-4-[(E)-(5-oxo-2-phenyl-1,3-oxazol-4-ylidene)methyl]phenyl] acetate
• 化学式: C₂₀H₁₅NO₆
• 分子量: 365.3
• InChiKey: LKTIYBGKWLNKGK-MHWRWJLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  91.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Process for producing N-acylphenylalanines
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0161796A1

  公开（公告）日：1985-11-21

  An N-acyl-substituted or unsubstituted phenylalanine is prepared by hydrolyzing a 2-substituted-4-substituted or unsubstituted benzylidene-5-oxazolone with an alkali, adjusting the reaction system containing its hydrolysis product with acid to a pH of 5 - 9 and reducing the resultant reaction solution catalytically in the presence of a palladium or platinum reducing catalyst. The reduction is carried out continuously without isolating the alkaline hydrolysis product, i.e., a substituted or unsubstituted N-acylaminocinnamic acid from the reaction system. The catalyst can be recovered after completion of the reduction and used repeatedly without additional treatment and without any observed lowering in its catalytic activity. Accordingly, the reductions using the recovered catalyst may proceed at pratically the same rate as reductions using a fresh catalyst.

  一种 N-酰基取代或未取代的苯丙氨酸是通过以下方法制备的：用碱水解 2-取代-4-取代或未取代的亚苄基-5-恶唑酮，用酸将含有其水解产物的反应体系调节到 pH 值为 5 - 9，然后在钯或铂还原催化剂存在下催化还原所得到的反应溶液。还原反应是连续进行的，无需从反应体系中分离出碱性水解产物，即取代或未取代的 N-酰基氨基肉桂酸。 催化剂可在还原完成后回收并重复使用，无需额外处理，也不会降低其催化活性。因此，使用回收催化剂进行还原的速度与使用新催化剂进行还原的速度基本相同。
• US4612388A
  申请人：——

  公开号：US4612388A

  公开（公告）日：1986-09-16