Benzyl 6-methyl-1,3-oxazinane-3-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl 6-methyl-1,3-oxazinane-3-carboxylate
• 英文别名: benzyl 6-methyl-1,3-oxazinane-3-carboxylate
• 化学式: C₁₃H₁₇NO₃
• 分子量: 235.28
• InChiKey: CFPHNFPVUKXFBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
  申请人：Novartis AG

  公开号：EP3514151A1

  公开（公告）日：2019-07-24

  PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.

  本研究公开了 PKC 抑制剂。这些 PKC 抑制剂可用于治疗 PKC 相关疾病，包括某些癌症。这些 PKC 抑制剂具有更低剂量下的更佳疗效，可实现肿瘤消退，并具有更好的效力、PK 特性、吸收、胃肠道耐受性和激酶选择性。
• [EN] THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS<br/>[FR] COMPOSÉS DE THIAZOLECARBOXAMIDE ET DE PYRIDINECARBOXAMIDE UTILES COMME INHIBITEURS DE KINASES PIM
  申请人：INCYTE CORP

  公开号：WO2014113388A1

  公开（公告）日：2014-07-24

  The present disclosure describes thiazole and pyridine carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein: X is C or N; A, B and D are rings; the bond— represents a normalized bond within the aromatic ring containing both an N and X, which formally is represented by a C=C bond when X is C and a single bond when X is N; ring A is of the formula (A-l) or (A-2): wherein El and E2 are rings; their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.