2,5-Dioxopyrrolidin-1-yl 2-(p-tolyl)acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-Dioxopyrrolidin-1-yl 2-(p-tolyl)acetate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 2-(4-methylphenyl)acetate
• 化学式: C₁₃H₁₃NO₄
• 分子量: 247.25
• InChiKey: STUVKASKZDJNHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CONJUGATES AND SMALL MOLECULES WHICH INTERACT WITH THE CD16A RECEPTOR
  申请人："Biointegrator" Limited Liability Company (OOO "Biointegrator")

  公开号：EP2947074A1

  公开（公告）日：2015-11-25

  The invention is related to medicine, in particular, to oncology and immunology. The novel compounds of the general formula 1 or 2, exhibiting affinity for CD16a receptor have been proposed. There were also proposed novel modified proteins active towards CD16a receptor, selected from antibody or autogen conjugated by a modifying compound selected from compound of the general formula 1 or 2, which stimulate and direct antibody-dependent cellular cytotoxicity. The novel modified proteins (conjugates) could be used for destruction of definite targeted group of cells in organism, for example, cancerous cells or autoimmune lymphocytes. There were also proposed methods for conjugate preparation, pharmaceutical composition, and medicament, comprising modified proteins for treating oncology and autoimmune diseases.

  本发明涉及医学，特别是肿瘤学和免疫学。已经提出了对 CD16a 受体具有亲和力的通式 1 或 2 的新型化合物。此外，还提出了对 CD16a 受体具有活性的新型修饰蛋白，这些蛋白选自抗体或自体原，与选自通式 1 或 2 化合物的修饰化合物共轭，可刺激和引导抗体依赖性细胞毒性。新型修饰蛋白（共轭物）可用于消灭生物体内的特定目标细胞群，例如癌细胞或自身免疫淋巴细胞。此外，还提出了包含修饰蛋白质的共轭物制备方法、药物组合物和药品，用于治疗肿瘤和自身免疫性疾病。
• REAGENTS AND METHODS FOR ESTERIFICATION
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20160297752A1

  公开（公告）日：2016-10-13

  Methods and reagents for esterification of biological molecules including proteins, polypeptides and peptides. Diazo compounds of formula I: where R is hydrogen, an alkyl, an alkenyl or an alkynyl, R A represents 1-5 substituents on the indicated phenyl ring and R M is an organic group, which includes a label, a cell penetrating group, a cell targeting group, or a reactive group or latent reactive group for reaction to bond to a label, a cell penetrating group, or a cell targeting group, among other organic groups are useful for esterification of biological molecules. Also provided are diazo compounds which are bifunctional and trifunctional coupling reagents as well as reagents for the synthesis of compounds of formula I.
• Reagents and Methods for Esterification
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20180037881A1

  公开（公告）日：2018-02-08

  Methods and reagents for esterification of biological molecules including proteins, polypeptides and peptides. Diazo compounds of formula I: where R is hydrogen, an alkyl, an alkenyl or an alkynyl, R A represents 1-5 substituents on the indicated phenyl ring and R M is an organic group, which includes a label, a cell penetrating group, a cell targeting group, or a reactive group or latent reactive group for reaction to bond to a label, a cell penetrating group, or a cell targeting group, among other organic groups are useful for esterification of biological molecules. Also provided are diazo compounds which are bifunctional and trifunctional coupling reagents as well as reagents for the synthesis of compounds of formula I.
• TRIFUNCTIONAL CONSTRUCTS WITH TUNABLE PHARMACOKINETICS USEFUL IN IMAGING AND ANTI-TUMOR THERAPIES
  申请人：Cornell University

  公开号：US20200405888A1

  公开（公告）日：2020-12-31

  The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer.
• US9790483B2
  申请人：——

  公开号：US9790483B2

  公开（公告）日：2017-10-17