5-[(2,5-Dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-[(2,5-Dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
• 化学式: C₂₁H₁₇N₃O₂S
• mdl: MFCD05625601
• 分子量: 375.4
• InChiKey: NCSHZXNGQYSKLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  80.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Oxazole and thiazole compounds as beta-catenin modulators and uses thereof
  申请人：Dasgupta Ramanuj

  公开号：US20090227624A1

  公开（公告）日：2009-09-10

  A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
• OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF
  申请人：DASGUPTA Ramanuj

  公开号：US20120264744A1

  公开（公告）日：2012-10-18

  A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-catenin. Oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
• METHODS OF DIFFERENTIATING STEM CELLS INTO ONE OR MORE CELL LINEAGES
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US20150329821A1

  公开（公告）日：2015-11-19

  The present disclosure provides an understanding of the regulation of the developmental phases of stem cells and their induction into relevant cell lineages, such as primitive streak, endoderm, mesoderm, or subterrotories of endoderm's. In particular, the present disclosure provides methods, culture medium and kits for the maintenance and differentiation of stem cells into relevant cell lineages.
• Methods of Producing Specialized Cardio-Like Cells from Stem Cells
  申请人：Emory University

  公开号：US20190136191A1

  公开（公告）日：2019-05-09

  This disclosure relates to method of differentiating stem cells to specific cardiac-like cells. In certain embodiments, the disclosure contemplates methods of generating left ventricular-like cells and the atrial-like cells by timing the exposure of dividing stem cells to retinoic acid (RA) or retinoic acid receptor inhibitors.
• US8252823B2
  申请人：——

  公开号：US8252823B2

  公开（公告）日：2012-08-28