5-chloro-2-(4-fluoro-2-methylphenoxy)-N-(4-fluoro-2-oxo-1,3-dihydropyridin-4-yl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-chloro-2-(4-fluoro-2-methylphenoxy)-N-(4-fluoro-2-oxo-1,3-dihydropyridin-4-yl)benzamide
• 化学式: C₁₉H₁₅ClF₂N₂O₃
• 分子量: 392.8
• InChiKey: CPIVXBJCAODTRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US20140213616A1

  公开（公告）日：2014-07-31

  The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

  该发明涉及式I和I'的吡啶酮酰胺化合物或其药学上可接受的盐，用作钠通道抑制剂：该发明还提供了包括该发明化合物的药学上可接受的组合物，以及使用这些组合物治疗各种疾病，包括疼痛的方法。
• PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US20160009743A1

  公开（公告）日：2016-01-14

  The invention relates to prodrug compounds of formula I: wherein R 2 , R 3 , R 5 , R 7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

  本发明涉及公式I的前药化合物：其中R2，R3，R5，R7和X如本文所定义。本发明还提供了包含本发明化合物的药学上可接受的组合物，并且提供了使用这些组合物治疗各种疾病（包括疼痛）的方法。公式I的化合物具有优越的溶解度和物理化学性质。
• Pyridone amides as modulators of sodium channels
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US10087143B2

  公开（公告）日：2018-10-02

  The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

  本发明涉及式 I 和 I′ 的吡啶酮酰胺化合物或其药学上可接受的盐类，可用作钠通道抑制剂： 本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗包括疼痛在内的各种疾病的方法。
• Prodrugs of pyridone amides useful as modulators of sodium channels
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US10787472B2

  公开（公告）日：2020-09-29

  The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

  本发明涉及式 I 的原药化合物： 其中 R2、R3、R5、R7 和 X 如本文所定义。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗包括疼痛在内的各种疾病的方法。式 I 的化合物具有良好的溶解性和理化性质。
• US9051270B2
  申请人：——

  公开号：US9051270B2

  公开（公告）日：2015-06-09