Aminophosphonous acid;[cyano-(3-phenoxyphenyl)methyl] 2,2-dichloro-1-(4-ethoxyphenyl)cyclopropane-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Aminophosphonous acid;[cyano-(3-phenoxyphenyl)methyl] 2,2-dichloro-1-(4-ethoxyphenyl)cyclopropane-1-carboxylate
• 英文别名: aminophosphonous acid;[cyano-(3-phenoxyphenyl)methyl] 2,2-dichloro-1-(4-ethoxyphenyl)cyclopropane-1-carboxylate
• 化学式: C26H25Cl2N2O6P
• 分子量: 563.4
• InChiKey: HKUOTUVOJNVDEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.66
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• METHOD FOR THE SOLID-PHASE BASED SYNTHESIS OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES
  申请人：Universität Hamburg

  公开号：EP2948467A1

  公开（公告）日：2015-12-02
• [EN] METHOD FOR THE SOLID-PHASE BASED SYNTHESIS OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES<br/>[FR] PROCÉDÉ POUR LA SYNTHÈSE À BASE DE PHASE SOLIDE DE CONJUGUÉS DE NUCLÉOSIDE À PONT PHOSPHATE
  申请人：UNIVERSITÄT HAMBURG

  公开号：WO2014114326A1

  公开（公告）日：2014-07-31

  The invention relates to a method for producing phosphate-bridged nucleoside conjugates, in particular poly- or oligonucleosides. In the method, an immobilized cyclosaligenyl derivative of a nucleoside, nucleotide, poly- or oligonucleotide, poly- or oligonucleoside, or an analog thereof, is synthesized, and the subsequent reaction with a nucleophile yields the desired phosphate-bridged nucleoside conjugate, which may subsequently be released from the solid phase.