Ethyl 2-(dimethylamino)-5-phenylbenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 2-(dimethylamino)-5-phenylbenzoate
• 英文别名: ethyl 2-(dimethylamino)-5-phenylbenzoate
• 化学式: C₁₇H₁₉NO₂
• 分子量: 269.34
• InChiKey: LWMXOYIILCMTIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• LIPASE INHIBITORS
  申请人：Technische Universität Graz

  公开号：EP2948433A1

  公开（公告）日：2015-12-02
• [EN] LIPASE INHIBITORS<br/>[FR] INHIBITEURS DE LIPASE
  申请人：TECH UNIVERSITÄT GRAZ

  公开号：WO2014114649A1

  公开（公告）日：2014-07-31

  The present invention provides a small molecule inhibitor for adipose triglyceride lipase (ATGL) with the molecule having IC 50 concentrations in the submicromolar range. The inhibitor has the basic structure (I) as disclosed herein and is a competitive inhibitor that does not affect the activity of other known acylglycerol hydrolases. The inhibitor is orally bioavailable and capable of inhibiting lipolysis in vivo, such that it is therefore capable of serving as lead structure for the identification of further inhibitors.