N-methyl-N,N',N'-tris(pyridin-2-ylmethyl)methanediamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-methyl-N,N',N'-tris(pyridin-2-ylmethyl)methanediamine
• 化学式: C₂₀H₂₃N₅
• 分子量: 333.4
• InChiKey: DQUVUVVUXNWPQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  45.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PHOTOSTABLE AIE LUMINOGENS FOR SPECIFIC MITOCHONDRIAL IMAGING AND ITS METHOD OF MANUFACTURING THEREOF
  申请人：The Hong Kong University of Science and Technology

  公开号：US20140212359A1

  公开（公告）日：2014-07-31

  AIE (aggregation-induced emission)-active TPE derivatives, TPE-TPP, TPE-MitoR and TPE-IQ are contemplated. These specific TPE derivatives are useful as fluorescent agents for mitochondrial imaging and as apoptosis inducers. Possessing high specificity to mitochondria, superior photostability and appreciable tolerance to microenvironment change, TPE derivatives are well-suited imaging agents for mitochondrial targeting and morphological change tracking. Because of their synthetic flexibility, TPE derivatives can be further modified as dual-functional probes for an array of applications such as sensing of ROS, metal ions, or pH change in mitochondria.

  活性聚集诱导发光（AIE）的TPE衍生物，TPE-TPP、TPE-MitoR和TPE-IQ被考虑。这些特定的TPE衍生物可用作线粒体成像的荧光试剂和凋亡诱导剂。具有对线粒体的高特异性、优越的光稳定性和对微环境变化的可观容忍度，TPE衍生物非常适合用作线粒体靶向成像和形态变化跟踪的成像试剂。由于其合成灵活性，TPE衍生物可以进一步改进为用于一系列应用的双功能探针，例如在线粒体中感测ROS、金属离子或pH变化。
• Photoactivatable Caged Compounds with AIE Characteristics: Method of Preparation and Applications
  申请人：TANG Benzhong

  公开号：US20150376112A1

  公开（公告）日：2015-12-31

  A photoactivatable caged compound (TPE-C) with AIE characteristics is designed and synthesized. TPE-C is non-emissive either in solution or in aggregated state, but its luminescence can be induced to emit strong cyan emission in aggregated state by UV irradiation. Such property enables TPE-C to be applied in photo-patterning and anti-counterfeiting related areas.
• US9315465B2
  申请人：——

  公开号：US9315465B2

  公开（公告）日：2016-04-19
• US9919995B2
  申请人：——

  公开号：US9919995B2

  公开（公告）日：2018-03-20
• [EN] AIE BIOPROBES EMITTING RED OR YELLOW FLUORESCENCE<br/>[FR] BIOSONDES À AIE ÉMETTANT UNE FLUORESCENCE ROUGE OU JAUNE
  申请人：UNIV HONG KONG SCIENCE & TECH

  公开号：WO2017080413A1

  公开（公告）日：2017-05-18

  The present subject matter relates to red emitting mitochondria-targeted aggregation induced emission (AIE) probes as an indicator for membrane potential and mouse sperm activity. The present subject matter relates to AIE-active fluorescent probes for reactive oxygen species (ROS) detection and related biological applications, such as inflammation imaging and glucose assay, as well as the preparation and application of red fluorescent AIEgens.