3-(cyclopropylmethoxy)-N-(3,5-dichloro-1-hydroxy-2-methyl-2H-pyridin-4-yl)-4-(difluoromethoxy)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(cyclopropylmethoxy)-N-(3,5-dichloro-1-hydroxy-2-methyl-2H-pyridin-4-yl)-4-(difluoromethoxy)benzamide
• 化学式: C₁₈H₁₈Cl₂F₂N₂O₄
• 分子量: 435.2
• InChiKey: PRGAEMRWAQHCBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  71
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] METHODS OF TREATING AUTOIMMUNE, RESPIRATORY AND INFLAMMATORY DISORDERS BY INHALATION OF ROFLUMILAST N-OXIDE<br/>[FR] PROCÉDÉS DE TRAITEMENT DE TROUBLES AUTO-IMMUNS, RESPIRATOIRES ET INFLAMMATOIRES PAR INHALATION DE N-OXYDE DE ROFLUMILAST
  申请人：INCOZEN THERAPEUTICS PVT LTD

  公开号：WO2014115127A1

  公开（公告）日：2014-07-31

  The present disclosure relates to pharmaceutical compositions useful for (and to a method of) treating autoimmune, respiratory and/or inflammatory diseases and conditions. The method involves administering to a subject in need thereof roflumilast N-oxide by inhalation. The present disclosure particularly relates to the treatment of asthma and chronic obstructive pulmonary disease (COPD) by administering roflumilast N-oxide by inhalation.