Bis(4-nitrophenyl) 2,2,4,4-tetramethylpentanedioate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: Bis(4-nitrophenyl) 2,2,4,4-tetramethylpentanedioate
• 英文别名: bis(4-nitrophenyl) 2,2,4,4-tetramethylpentanedioate
• 化学式: C21H22N2O8
• 分子量: 430.4
• InChiKey: XZCWFRYLTDWMJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  144
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Nanoparticles having poly(ester amide) polymer cores as drug delivery vehicles
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US11123304B2

  公开（公告）日：2021-09-21

  This disclosure relates to nanoparticles comprising a core comprising a poly(ester amide) polymer comprising a repeating unit of Formula (Ia): and a repeating unit of Formula (Ib): wherein W1, W2, X1, A1, X2, A2, and X3 are as described herein, a payload molecule within the core, and a surface layer comprising a targeting ligand that binds or reacts selectively with a receptor on the outside surface of a cell. Methods of making such nanoparticles, and methods of using such nanoparticles as drug delivery vehicles, are also provided.

  本公开涉及纳米颗粒，其核由包含式 (Ia) 重复单元的聚酯酰胺聚合物组成： 和式(Ib)的重复单元： 其中 W1、W2、X1、A1、X2、A2 和 X3 如本文所述，核心内有有效载荷分子，表面层包含靶向配体，可选择性地与细胞外表面的受体结合或反应。还提供了制造这种纳米颗粒的方法和使用这种纳米颗粒作为药物输送载体的方法。
• POLY(ESTER AMIDE)S AND POLY(ESTER ETHER AMIDE)S WITH ALIPHATIC POLYESTERS, METHOD OF MAKING SAME, AND USES THEREOF
  申请人：Chu Chih-Chang

  公开号：US20140213738A1

  公开（公告）日：2014-07-31

  Polymers and copolymers having one or more aliphatic polyester groups or blocks. For example, the aliphatic polyester groups or blocks can be derived from a caprolactone such as, for example, ε-caprolactone. The polymers and copolymers can have desirable properties such as, for example, improved solubility and improved thermal properties.
• Particles as Delivery Systems
  申请人：Farokhzad Omid C.

  公开号：US20190350870A1

  公开（公告）日：2019-11-21

  This disclosure relates to particles, compositions, methods of making, and methods of use thereof.