2-(Pyridin-2-yldisulfanyl)propan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(Pyridin-2-yldisulfanyl)propan-1-amine
• 英文别名: 2-(pyridin-2-yldisulfanyl)propan-1-amine
• 化学式: C₈H₁₂N₂S₂
• 分子量: 200.3
• InChiKey: YVFLKEHIGMOLQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  89.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ANTHRACYCLINE DISULFIDE INTERMEDIATES, ANTIBODY-DRUG CONJUGATES AND METHODS
  申请人：GENENTECH, INC.

  公开号：US20160074528A1

  公开（公告）日：2016-03-17

  The invention provides antibody-drug conjugates comprising an antibody conjugated to an anthracycline drug moiety via a disulfide linker, anthracycline disulfide intermediates, and methods of using the antibody-drug conjugates.

  该发明提供了抗体-药物偶联物，包括通过二硫键连接器将抗体与蒽环类药物部分偶联的抗体，蒽环二硫中间体，以及使用抗体-药物偶联物的方法。
• Anthracycline disulfide intermediates, antibody-drug conjugates and methods
  申请人：Genentech, Inc.

  公开号：US10149913B2

  公开（公告）日：2018-12-11

  The invention provides antibody-drug conjugates comprising an antibody conjugated to an anthracycline drug moiety via a disulfide linker, anthracycline disulfide intermediates, and methods of using the antibody-drug conjugates.

  本发明提供了抗体-药物共轭物，包括通过二硫连接体与蒽环类药物分子共轭的抗体、蒽环类二硫中间体以及使用抗体-药物共轭物的方法。
• Cyclodextrin-Based Polymers for Therapeutic Delivery
  申请人：Cerulean Pharma Inc.

  公开号：US20140213504A1

  公开（公告）日：2014-07-31

  Described herein are CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. Also disclosed are methods of using (e.g., to treat a disorder) the CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates.