(2-Bromo-4-cyanophenyl)-[[5-oxo-2-[3-(trifluoromethyl)anilino]cyclopenten-1-yl]methyl]carbamic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Bromo-4-cyanophenyl)-[[5-oxo-2-[3-(trifluoromethyl)anilino]cyclopenten-1-yl]methyl]carbamic acid
• 英文别名: (2-bromo-4-cyanophenyl)-[[5-oxo-2-[3-(trifluoromethyl)anilino]cyclopenten-1-yl]methyl]carbamic acid
• 化学式: C₂₁H₁₅BrF₃N₃O₃
• 分子量: 494.3
• InChiKey: DGWSOAAAUISRRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  93.4
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160031830A1

  公开（公告）日：2016-02-04

  Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD. Exemplary is

  式1的替代二氢嘧啶酮是中性粒细胞弹性蛋白酶抑制剂，可用作治疗COPD等疾病的药物。
• [EN] SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY<br/>[FR] DIHYDROPYRIMIDINONES BICYCLIQUES SUBSTITUÉES ET LEUR UTILISATION À TITRE D'INHIBITEURS DE L'ACTIVITÉ ÉLASTASE NEUTROPHILE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2014122160A1

  公开（公告）日：2014-08-14

  This invention relates to substituted bicyclic dihydropyrimidinones of formula (I) and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

  这项发明涉及公式（I）的取代双环二氢嘧啶酮及其用作中性粒细胞弹性蛋白酶活性抑制剂的用途，包含它们的药物组合物，以及将其用作治疗和/或预防肺部、胃肠道和泌尿系统疾病、皮肤和眼睛的炎症性疾病以及其他自身免疫和过敏性疾病、移植排斥反应和肿瘤性疾病的药剂的方法。
• US9290459B1
  申请人：——

  公开号：US9290459B1

  公开（公告）日：2016-03-22
• US9458113B2
  申请人：——

  公开号：US9458113B2

  公开（公告）日：2016-10-04
• [EN] SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY<br/>[FR] DIHYDROPYRIMIDINONES BICYCLIQUES SUBSTITUÉES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE L'ACTIVITÉ DE L'ÉLASTASE NEUTROPHILE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2016016363A1

  公开（公告）日：2016-02-04

  This invention relates to substituted dihydropyrimidinones of formula (I) and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.