3,4-dimethyl-N-(3,4,5-trimethoxybenzyl)aniline | 5557-60-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dimethyl-N-(3,4,5-trimethoxybenzyl)aniline
• 英文别名: 3,4-dimethyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline
• CAS: 5557-60-8
• 化学式: C₁₈H₂₃NO₃
• 分子量: 301.4
• InChiKey: RZQZRHMSAFNHBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• DEATH RECEPTOR SENSITIZING COMPOUNDS AND METHODS OF USE THEREFOR
  申请人：Schimmer Aaron D.

  公开号：US20080166378A1

  公开（公告）日：2008-07-10

  Methods of identifying death receptor sensitizing compounds and methods of using death receptor sensitizing compounds are provided.
• Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands
  申请人：Reed John C.

  公开号：US20080206287A1

  公开（公告）日：2008-08-28

  Cyclosporin A has been discovered to sensitize cancers resistant to TNF-family death receptors such as TRAIL and Fas to ligand-mediated apoptosis. Therefore, compositions that include cyclosporin A are useful in treating such cancers.
• US8008354B2
  申请人：——

  公开号：US8008354B2

  公开（公告）日：2011-08-30