N,N-Dimethyl(vinylbenzyl)amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-Dimethyl(vinylbenzyl)amine
• 英文别名: 1-(3-ethenylphenyl)-N,N-dimethylmethanamine
• 化学式: C₁₁H₁₅N
• mdl: MFCD09910358
• 分子量: 161.24
• InChiKey: CGQMSVZSAGRUJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1<br/>[FR] PYRIDINES SUBSTITUÉES EN TANT QU'INHIBITEURS DE DNMT1
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2017216726A1

  公开（公告）日：2017-12-21

  The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

  该发明涉及取代吡啶衍生物。具体而言，该发明涉及符合以下式（Iar）的化合物：（Iar）其中Yar、X1ar、X2ar、R1ar、R2ar、R3ar、R4ar和R5ar如本文所定义；或其药学上可接受的盐或前药。该发明的化合物是DNMT1的选择性抑制剂，可用于治疗癌症、癌前综合征、β血红蛋白病、镰状细胞病、镰状细胞贫血、β地中海贫血以及与DNMT1抑制相关的疾病。因此，该发明进一步涉及包含该发明化合物的药物组合物。该发明还进一步涉及使用该发明化合物或包含该发明化合物的药物组合物抑制DNMT1活性和治疗相关疾病的方法。
• CONJUGATED DIENE POLYMER PRODUCTION METHOD, AND CONJUGATED DIENE POLYMER COMPOSITION PRODUCTION METHOD
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20150005440A1

  公开（公告）日：2015-01-01

  A method for producing a conjugated diene-based polymer is provided, in which compounds of formulas (2) and (3) and a conjugated diene compound are polymerized using a compound of formula (1), and then a compound containing a nitrogen atom and/or a silicon atom is reacted with an active end of the polymer formed via the polymerization, R 11 represents a hydrocarbylene group, R 12 and R 13 each represent an optionally substituted hydrocarbyl group or a trihydrocarbylsilyl group, or R 12 is bonded to R 3 and the group in which R 12 is bonded to R 13 represents a hydrocarbylene group optionally having a nitrogen and/or oxygen atom, —Si(R 14 ) 2 —(CH 2 ) x —Si(R 14 ) 2 —, or —Si(R 15 ) 2 —(CH 2 ) y − , and M represents an alkali metal atom, E 2 -A 2 (2) E 3 -A 3 (3) E 2 and E 3 each represent a hydrocarbyl group having a polymerizable carbon-carbon double bond, A 2 represents a substituted amino group or a nitrogen-containing heterocyclic group, and A 3 represents a substituted silyl group.

  提供一种制备基于共轭二烯的聚合物的方法，其中使用式(1)的化合物聚合式(2)和(3)的化合物以及共轭二烯化合物，然后使用含有氮原子和/或硅原子的化合物与通过聚合形成的聚合物的活性末端反应。其中，R11代表烃基烷基，R12和R13分别代表可选取代的烃基或三烷基硅基，或者R12与R3结合，R12与R13结合的基团可选地具有氮和/或氧原子，-Si(R14)2-(CH2)x-Si(R14)2-，或-Si(R15)2-(CH2)y-，M代表碱金属原子，E2-A2(2)E3-A3(3)中，E2和E3分别代表具有可聚合碳-碳双键的烃基，A2代表取代的氨基或含氮杂环基团，A3代表取代的硅基。
• Ink set and media for ink-jet printing
  申请人：Hewlett-Packard Development Company, L.P.

  公开号：EP1690904A1

  公开（公告）日：2006-08-16

  An ink set for ink-jet printing includes a medium cyan ink-jet ink, a magenta ink-jet ink, and a gray ink-jet ink. Each of the medium cyan ink-jet ink, the magenta ink-jet ink, and the gray ink-jet ink are configured to have a lightness at a predetermined/given number of drops per unit area of an image-receiving medium such that the lightness of each of the inks are substantially matched.

  喷墨打印墨水组包括中青色喷墨墨水、品红色喷墨墨水和灰色喷墨墨水。中青色喷墨墨水、品红色喷墨墨水和灰色喷墨墨水中的每种墨水都被配置为在图像接收介质的单位面积上具有预定/给定滴数的亮度，从而使每种墨水的亮度基本匹配。
• STAR POLYMER AND PROCESS FOR PRODUCTION THEREOF
  申请人：NIPPON SODA CO., LTD.

  公开号：EP1923418A1

  公开（公告）日：2008-05-21

  The present invention provides a novel narrow distribution dendrimer-like star polymer having a controlled molecular structure, and a method capable of easily producing the star polymer. Disclosed is a polymer comprising a core portion and an arm portion, wherein the arm portion includes a first generation composed of a polymer chain and a second generation composed of a polymer chain formed at the outer shell of the first generation, the number of arms of the second generation is larger than the number of arms of the first generation, the first generation composed of the polymer chain is a polymer chain derived from a monomer having a polymerizable double bond, and the ratio of the weight average molecular weight (Mw) to the number average molecular weight (Mn), (Mw/Mn), of the star polymer is within a range from 1.001 to 2.50. A compound containing a functional group capable of reacting with an anion, which serves as a core portion, is reacted with a polymer chain containing two or more functional groups and an anion end which serves as an arm portion.

  本发明提供了一种具有可控分子结构的新型窄分布树枝状星形聚合物，以及一种能够轻松生产该星形聚合物的方法。 本发明公开了一种聚合物，包括芯部和臂部，其中臂部包括由聚合物链组成的第一代和由在第一代外壳上形成的聚合物链组成的第二代，第二代的臂数大于第一代的臂数、由聚合物链组成的第一代是由具有可聚合双键的单体衍生的聚合物链，且星形聚合物的重量平均分子量（Mw）与数量平均分子量（Mn）之比（Mw/Mn）在 1.001 至 2.50。一种含有能与阴离子反应的官能团（作为核心部分）的化合物与含有两个或两个以上官能团和阴离子末端（作为臂部分）的聚合物链反应。
• Star polymer and method for producing the same
  申请人：Nippon Soda Co., Ltd.

  公开号：EP2311900A1

  公开（公告）日：2011-04-20

  The present invention provides a novel narrow distribution dendrimer-like star polymer having a controlled molecular structure, and a method capable of easily producing the star polymer. Disclosed is a polymer comprising a core portion and an arm portion, wherein the arm portion includes a first generation composed of a polymer chain and a second generation composed of a polymer chain formed at the outer shell of the first generation, the number of arms of the second generation is larger than the number of arms of the first generation, the first generation composed of the polymer chain is a polymer chain derived from a monomer having a polymerizable double bond, and the ratio of the weight average molecular weight (Mw) to the number average molecular weight (Mn), (Mw/Mn), of the star polymer is within a range from 1.001 to 2.50. A compound containing a functional group capable of reacting with an anion, which serves as a core portion, is reacted with a polymer chain containing two or more functional groups and an anion end which serves as an arm portion.

  本发明提供了一种具有可控分子结构的新型窄分布树枝状星形聚合物，以及一种能够轻松生产该星形聚合物的方法。 本发明公开了一种聚合物，包括芯部和臂部，其中臂部包括由聚合物链组成的第一代和由在第一代外壳上形成的聚合物链组成的第二代，第二代的臂数大于第一代的臂数、由聚合物链组成的第一代是由具有可聚合双键的单体衍生的聚合物链，且星形聚合物的重量平均分子量（Mw）与数量平均分子量（Mn）之比（Mw/Mn）在 1.001 至 2.50。一种含有能与阴离子反应的官能团（作为核心部分）的化合物与含有两个或两个以上官能团和阴离子末端（作为臂部分）的聚合物链反应。