(1R,2R)-N-(2,4-difluorobenzyl)-9’-hydroxy-2’-isopropyl-2-(methoxymethyl)-1’,8’-dioxo-1‘,2’,3’,8’-tetrahydrospiro[cyclopropane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (1R,2R)-N-(2,4-difluorobenzyl)-9’-hydroxy-2’-isopropyl-2-(methoxymethyl)-1’,8’-dioxo-1‘,2’,3’,8’-tetrahydrospiro[cyclopropane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide hydrochloride
• 英文别名: (2'R,4R)-N-[(2,4-difluorophenyl)methyl]-9-hydroxy-2'-(methoxymethyl)-1,8-dioxo-2-propan-2-ylspiro[3H-pyrido[1,2-a]pyrazine-4,1'-cyclopropane]-7-carboxamide;hydrochloride
• 化学式: C₂₃H₂₅F₂N₃O₅*ClH
• 分子量: 497.926
• InChiKey: NWMBRUHIBVYUDN-ABAHCFJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  99.2
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR
  申请人：JAPAN TOBACCO INC.

  公开号：US20140221378A1

  公开（公告）日：2014-08-07

  Provided is a substituted spiropyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, which is useful as an anti-HIV agent. The present invention relates to a compound represented by the following formula [I] or [II] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.

  提供了一种替代的螺环吡啶并[1,2-a]吡嗪衍生物或其药用盐，其作为一种抗HIV药物。本发明涉及以下式[I]或[II]所表示的化合物或其药用盐： 其中每个符号如规范中定义的那样。
• SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR
  申请人：Japan Tobacco, Inc.

  公开号：EP2940019A1

  公开（公告）日：2015-11-04

  Provided is a substituted spiropyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, which is useful as an anti-HIV agent. The present invention relates to a compound represented by the following formula [I] or [II] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.

  本发明提供了一种取代的螺吡啶并[1,2-a]吡嗪衍生物或其药学上可接受的盐，可用作抗艾滋病毒药物。本发明涉及下式[I]或[II]代表的化合物或其药学上可接受的盐： 其中各符号如说明书中所定义。
• Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor
  申请人：JAPAN TOBACCO INC.

  公开号：US10087178B2

  公开（公告）日：2018-10-02

  Provided is a substituted spiropyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, which is useful as an anti-HIV agent. The present invention relates to a compound represented by the following formula [I] or [II] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.

  本发明提供了一种取代的螺吡啶并[1,2-a]吡嗪衍生物或其药学上可接受的盐，可用作抗艾滋病毒药物。本发明涉及下式[I]或[II]代表的化合物或其药学上可接受的盐： 其中各符号如说明书中所定义。