1-aminotetradecan-2-ol | 14627-63-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-aminotetradecan-2-ol
• 英文别名: 1-Amino-tetradecan-2-ol
• CAS: 14627-63-5
• 化学式: C₁₄H₃₁NO
• 分子量: 229.406
• InChiKey: HKGKYUVCADNOOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-二氢-9,10-二羟基-1,4-蒽二酮 、 1-aminotetradecan-2-ol 以 乙醇 为溶剂， 反应 12.0h， 生成 1-Hydroxy-4-(2-hydroxytetradecylamino)anthracene-9,10-dione
  参考文献：
  名称：

  Synthesis of 1,4-Anthracene-9,10-dione Derivatives and Their Regulation of Nitric Oxide, IL-1βand TNF-αin Activated RAW264.7 Cells

  摘要：

  Mitoxantrone is an anthracenedione antineoplastic and immunosuppressive agent approved for multiple sclerosis treatment. Novel mono‐ and disubstituted anthraquinone derivatives, analogues of mitoxantrone, were synthesized through the addition of lipophilic amino alcohols and evaluated for their effect on IL‐1β, TNF‐α and nitric oxide production by LPS/IFN‐γ‐stimulated RAW264.7 cells. The disubstituted 1,4‐anthracene‐9,10‐dione 10 showed significant inhibition of nitric oxide, TNF‐α and IL‐1β production at the concentration of 5 μg/mL, with a much lower cytotoxicity than mitoxantrone. The monosubstituted 3, 4, 11, 12 and 13 also displayed a moderate to good inhibitory capacity on IL‐1β production. However, the methylated compounds 11, 12 and 13 failed to inhibit the TNF‐α production, and compound 13 was the only one to decrease the production of nitric oxide. None of these derivatives was toxic at the tested concentrations. Compounds 10 and 13 had better inhibitory capacity of the inflammatory mediators analyzed, with reliable viability of the cells.

  DOI：

  10.1111/cbdd.12183
• 作为产物：
  描述：

  1,2-十四碳二醇 在 吡啶 、 sodium azide 、 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-aminotetradecan-2-ol
  参考文献：
  名称：

  一种新的亲脂性氨基醇，在化学上类似于化合物FTY720，可通过PI3K / Akt途径抑制来减轻实验性自身免疫性脑脊髓炎的发病机理。

  摘要：

  实验性自身免疫性脑脊髓炎（EAE）是用于研究多发性硬化症（MS）的主要动物模型之一。在某些炎症性疾病模型中，已经研究了具有免疫调节活性的长链亲脂性氨基醇，但这些化合物在EAE和MS中的作用仍然未知。在这项研究中，我们调查了亲脂性氨基醇4b是否会改善C57Bl /的EAE的临床体征并减少脊髓的脱髓鞘过程和神经炎症参数以及腹股沟淋巴结的炎症过程。 MOG 35-55和百日咳刺激后，EAE诱发了6只小鼠毒素。从疾病的临床症状发作之日（第10天）开始，到免疫接种后第20天结束，口服给予4b治疗（1.0 mg / kg /天）。这种治疗方法能够减少腹股沟淋巴结的细胞数量，减少炎症细胞向中枢神经系统（CNS）的迁移以及小胶质细胞增生，星形胶质增生以及趋化因子和促炎性细胞因子的产生，因此增加了EAE小鼠的IL-10抗炎细胞因子水平。用4b处理后，EAE小鼠中枢神经系统中Akt磷酸化的抑制表明4b的免疫调节作用与PI3K

  DOI：

  10.1016/j.intimp.2020.106919

文献信息

• Method and apparatus for producing synergistic biocide
  申请人：Singleton L. Freddie

  公开号：US20070049642A1

  公开（公告）日：2007-03-01

  An apparatus and methods to produce synergistic mixtures (or combinations) of haloamines to control growth of microorganisms in aqueous systems are disclosed. The apparatus and methods to produce synergistic mixtures entails producing a batch quantity of a haloamine and converting part of the haloamine to a second haloamine species to form the synergistic mixture.

  本发明涉及一种用于控制水系中微生物生长的卤胺协同混合物（或组合物）的装置和方法。制备卤胺协同混合物的装置和方法包括制备一批量的卤胺，并将部分卤胺转化为第二种卤胺物种以形成协同混合物。
• Polymers with hydrophobe bunches
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0096882A1

  公开（公告）日：1983-12-28

  A water-soluble, thermoplastic, organic polymer is disclosed having segments of bunched monovalent hydrophobic groups. These polymers provide superior thickening and leveling in aqueous systems, through micelle-like associations, and aid suspension of particulate materials in non-aqueous systems.

  本发明公开了一种水溶性热塑性有机聚合物，这种聚合物具有成串的单价疏水基团，通过胶束状结合，在水性体系中具有优异的增稠和流平效果，并有助于颗粒材料在非水性体系中的悬浮。
• Carbazole photoinitiators for the photopolymerization of unsaturated compounds
  申请人：ADEKA ARGUS CHEMICAL CO., Ltd.

  公开号：EP0171600A1

  公开（公告）日：1986-02-19

  Carbazole photoinitiators for the photopolymerization of unsaturated compounds are provided, having the formulae: wherein: R1 and R2 are each alkyl having from one to about eighteen carbon atoms; or are taken together to form alkylene having from about two to about twelve carbon atoms; R3 is selected from the group consisting of hydrogen; alkyl having from one to about eighteen carbon atoms; and acyl having from about two to about twelve carbon atoms; in which R5 is selected from the group consisting of hydrogen; alkyl and alkenyl having from one to about eighteen carbon atoms; and R6 and R7 are selected from the group consisting of alkyl; hydroxyalkyl having from one to about eighteen carbon atoms; and R6 and R7 taken together to form alkylene having from about two to about twelve carbon atoms; and oxadialkylene and iminodialkylene having from four to about twenty-four carbon atoms: Y2 is selected from the group consisting of hydrogen. halogen, and nitro; R4 is a direct linkage (-) or alkylene having from about two to about twelve carbon atoms; in which: R8 is alkylene having from about two to about twelve carbon atoms; R9 and R10 are alkyl having from one to about eighteen carbon atoms; or are taken together to form alkylene having from about two to about twelve carbon atoms.

  本发明提供了用于不饱和化合物光聚合的咔唑光引发剂，其化学式为 其中 R1 和 R2 分别是具有 1 至约 18 个碳原子的烷基；或共同形成具有约 2 至约 12 个碳原子的亚烷基； R3 选自氢、具有 1 至 18 个碳原子的烷基和具有 2 至 12 个碳原子的酰基组成的组； 其中 R5 选自由氢、具有 1 至约 18 个碳原子的烷基和烯基组成的组；R6 和 R7 选自由烷基、具有 1 至约 18 个碳原子的羟基烷基、R6 和 R7 共同形成的具有约 2 至约 12 个碳原子的亚烷基、以及具有 4 至约 24 个碳原子的氧二亚烷基和亚二亚烷基组成的组： Y2 选自氢、卤素和硝基组成的组； R4 是直接连接（-）或具有约 2 至约 12 个碳原子的亚烷基； 其中 R8 是具有约 2 至约 12 个碳原子的亚烷基； R9 和 R10 是具有 1 至约 18 个碳原子的烷基；或共同形成具有约 2 至约 12 个碳原子的亚烷基。
• Azo compound and aqueous ink composition comprising the same
  申请人：TAOKA CHEMICAL CO., LTD

  公开号：EP0194885A1

  公开（公告）日：1986-09-17

  An azo compound of the formula wherein M1. M2 and M3 are, the same or different, each a hydrogen atom, an alkali metal atom, an ammonium group or an organic ammonium group; R1 and R2 are, the same or different, each a C-c3 alkyl group, a C1-C3 alkoxy group, a halogen atom or a hydrogen atom; m is 1 or 2; and X and Y are, the same or different, each a C6-C18 alkylamine, alkoxyalkylamine, arylamine, aralkylamine, alkanolamine or alkarylamine residue, which is useful as a magenta color dyestuff for an aqueous ink composition, particularly for ink jet recording.

  式中的偶氮化合物 其中 M1.M2和M3相同或不同，各自为氢原子、碱金属原子、铵基团或有机铵基团；R1和R2相同或不同，各自为C-c3烷基、C1-C3烷氧基、卤素原子或氢原子；m为1或2；X和Y相同或不同，各自为C6-C18烷基胺、烷氧基烷基胺、芳基胺、芳基胺、烷醇胺或烷芳基胺残基，可用作水性油墨组合物的洋红色染料，特别是用于喷墨记录。
• Mouldable composition
  申请人：SANYO CHEMICAL INDUSTRIES LTD.

  公开号：EP0329475A2

  公开（公告）日：1989-08-23

  Mouldable compositions comprising a metallic powder or a combination thereof with ceramic powder, mixed with an organic binder are disclosed, at least a part of which binder comprises a synthetic resin component (A) having a heat deformation temperature of 130°C or higher. The component A may be used in combination with another component (B) having a melting point of 30°C - 100°C, with or without another thermoplastic component (C), having a heat deformation temperature of 130°C or less. Mouldable compositions, comprising metallic and/or ceramic powder mixed with an organic binder comprising a secondary or tertiary amine (D), or a combination thereof with a thermoplastic resin (E), are also disclosed.

  本发明公开了由金属粉末或其与陶瓷粉末的组合与有机粘合剂混合而成的可模塑组合物，其中至少一部分粘合剂包括热变形温度为 130°C 或更高的合成树脂成分（A）。成分 A 可与另一种熔点为 30°C - 100°C 的成分 (B) 结合使用，也可与另一种热塑性成分 (C) 结合使用，后者的热变形温度为 130°C 或更低。此外，还公开了由金属和/或陶瓷粉末与有机粘合剂（包括仲胺或叔胺）（D）或其与热塑性树脂（E）的组合物）混合而成的可模塑组合物。