2-(4-Methyl-3-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Methyl-3-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one
• 化学式: C₁₈H₁₈N₂O₄S₂
• 分子量: 390.5
• InChiKey: MATJNQHJABVSQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY
  申请人：Washington University

  公开号：US20160046651A1

  公开（公告）日：2016-02-18

  Compounds are disclosed that inhibit the methylerythritol cytidyltransferase (IspD) enzyme in the non-mevalonate pathway (MEP pathway), which is present in many organisms including the P. falciparum parasite. Inhibitors of the IspD enzyme in the non-mevalonate pathway of the P. falciparum parasite are useful for treating malaria.