N-[4-[(2-methoxyphenyl)sulfamoyl]phenyl]-3-phenylsulfanylpropanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[(2-methoxyphenyl)sulfamoyl]phenyl]-3-phenylsulfanylpropanamide
• 化学式: C₂₂H₂₂N₂O₄S₂
• 分子量: 442.6
• InChiKey: NUVRZWPTZCUERF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• INHIBITORS OF RAC1 AND USES THEREOF FOR INDUCING BRONCHODILATATION
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：US20210077508A1

  公开（公告）日：2021-03-18

  The present invention concerns a compound having the following formula (I): wherein: —A is in particular —N(R′ a )—C(═O)—R, R′ a being H or a (C 1 -C 6 )alkyl group, and R being preferably a group having the following formula (II): —X is in particular chosen from the group consisting of: —SO 2 —N(R′ b )—, R′ b being H or a (C 1 -C 6 )alkyl group, —N(R″ b )—SO 2 —, R″b being H or a (C 1 -C 6 )alkyl group, —CO—NH—, and —NH—CO—, for use for the treatment of pathologies characterized by bronchoconstriction, such as asthma.