2-[4-Cyclobutyl-2-fluoro-3-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]pyrazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-Cyclobutyl-2-fluoro-3-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]pyrazine
• 英文别名: 2-[4-cyclobutyl-2-fluoro-3-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]pyrazine
• 化学式: C₂₂H₁₈F₄N₂O
• 分子量: 402.4
• InChiKey: HKYFRYFERDRWPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• FLAP MODULATORS
  申请人：ECCLES Wendy

  公开号：US20150368270A1

  公开（公告）日：2015-12-24

  The present invention relates to compounds of Formula (I), or a form thereof wherein ring A, R 1 , L and R 2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

  本发明涉及式(I)的化合物，或其形式，其中环A，R1，L和R2如本文所定义，用作FLAP调节剂。本发明还涉及包含式(I)化合物的制药组合物。制备和使用式(I)化合物的方法也在本发明的范围内。
• US9732093B2
  申请人：——

  公开号：US9732093B2

  公开（公告）日：2017-08-15
• [EN] FLAP MODULATORS<br/>[FR] MODULATEURS DE FLAP
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014121040A1

  公开（公告）日：2014-08-07

  The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, L and R2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.