3-(5-Aminopyrazin-2-yl)-2-fluoro-6-[4-(trifluoromethyl)phenyl]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(5-Aminopyrazin-2-yl)-2-fluoro-6-[4-(trifluoromethyl)phenyl]phenol
• 英文别名: 3-(5-aminopyrazin-2-yl)-2-fluoro-6-[4-(trifluoromethyl)phenyl]phenol
• 化学式: C₁₇H₁₁F₄N₃O
• 分子量: 349.28
• InChiKey: ZGXNUWNCTJBHQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  72
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• FLAP MODULATORS
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP3070085A1

  公开（公告）日：2016-09-21

  The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, R2, R3, R3', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

  本发明涉及式（I）化合物、 或其形式，其中环 A、R1、R2、R3、R3'、L、W 和 V 如本文所定义，可用作 FLAP 调节剂。本发明还涉及包含式（I）化合物的药物组合物。式（I）化合物的制造和使用方法也属于本发明的范围。
• [EN] FLAP MODULATORS<br/>[FR] MODULATEURS FLAP
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014121055A2

  公开（公告）日：2014-08-07

  The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A1, R1, R2, R3, R3', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.