3-[(2-Bromophenyl)methyl]pyrido[1,2-a]pyrimidin-2-one | 1449481-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 3-[(2-Bromophenyl)methyl]pyrido[1,2-a]pyrimidin-2-one
• 英文别名: 3-[(2-bromophenyl)methyl]pyrido[1,2-a]pyrimidin-2-one
• CAS: 1449481-49-5
• 化学式: C₁₅H₁₁BrN₂O
• 分子量: 315.169
• InChiKey: VMLMSYLGBHBVHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 methyl 2-(acetoxy(2-bromophenyl)methyl)acrylate 以 neat (no solvent) 为溶剂， 生成 3-[(2-Bromophenyl)methyl]pyrido[1,2-a]pyrimidin-2-one
  参考文献：
  名称：

  Microwave-assisted cyclocondensation: a rapid and solvent-free synthesis of 3-benzyl-2H-pyrido[1,2-a]pyrimidin-2-one derivatives

  摘要：

  Microwave-induced cyclocondensation of methyl 2-(acetoxy(phenyl)methyl)acrylate with 2-aminopyridines under catalyst and solvent-free conditions has been achieved for a rapid synthesis of 3-substituted-2H-pyrido[1,2-a]pyrimidin-2-ones in good yields with high selectivity in short reaction times. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.138

文献信息

• Microwave-assisted cyclocondensation: a rapid and solvent-free synthesis of 3-benzyl-2H-pyrido[1,2-a]pyrimidin-2-one derivatives
  作者：S. Satyanarayana、K. Praveen Kumar、P. Lakshmi Reddy、R. Narender、G. Narasimhulu、B.V. Subba Reddy

  DOI：10.1016/j.tetlet.2013.06.138

  日期：2013.9

  Microwave-induced cyclocondensation of methyl 2-(acetoxy(phenyl)methyl)acrylate with 2-aminopyridines under catalyst and solvent-free conditions has been achieved for a rapid synthesis of 3-substituted-2H-pyrido[1,2-a]pyrimidin-2-ones in good yields with high selectivity in short reaction times. (C) 2013 Elsevier Ltd. All rights reserved.