5-N-[[4-[2-[bis(2-hydroxyethyl)amino]ethylcarbamoyl]phenyl]methyl]-2-N-[(E)-[5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl]methylideneamino]thiophene-2,5-dicarboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-N-[[4-[2-[bis(2-hydroxyethyl)amino]ethylcarbamoyl]phenyl]methyl]-2-N-[(E)-[5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl]methylideneamino]thiophene-2,5-dicarboxamide
• 化学式: C₃₅H₄₁N₅O₆S₂
• 分子量: 691.9
• InChiKey: ACYJOWKLDGGBGB-BBUXEPKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  48
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  220
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2765187A1

  公开（公告）日：2014-08-13

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, comprising separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein R1 to R7, W, X, Y, Z, Ar1 and n are as defined in the description) to differentiate them into megakaryocytes and/or platelets.

  提供了一种诱导多能干细胞产生巨核细胞和/或血小板的制剂，该制剂可用于治疗伴随血小板减少的疾病。 一种生产巨核细胞和/或血小板的方法，包括在多能干细胞产生的囊状结构中将造血祖细胞从隔细胞中分离出来，并在由式（I）代表的化合物（其中R1至R7、W、X、Y、Z、Ar1和n如描述中所定义）存在下体内外培养造血祖细胞，使其分化成巨核细胞和/或血小板。