2-(4-Ethenylphenyl)-5-methyl-1,3,4-thiadiazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Ethenylphenyl)-5-methyl-1,3,4-thiadiazole
• 英文别名: 2-(4-ethenylphenyl)-5-methyl-1,3,4-thiadiazole
• 化学式: C₁₁H₁₀N₂S
• 分子量: 202.28
• InChiKey: HIANDGIAOKQSNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS
  申请人：Omeros Corporation

  公开号：US20140228581A1

  公开（公告）日：2014-08-14

  Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.

  本发明揭示了一种抑制PDE10的化合物，其具有治疗多种疾病的功效，包括（但不限于）精神病、焦虑、运动障碍和/或神经系统疾病，如帕金森病、亨廷顿病、阿尔茨海默病、脑炎、恐惧症、癫痫、失语症、贝尔氏麻痹、脑瘫、睡眠障碍、疼痛、抽动症、精神分裂症、妄想症、药物诱导的精神病和惊恐障碍以及强迫症。此外，还提供了该化合物的药物可接受盐、立体异构体、溶剂合物和前药。本发明还揭示了将化合物与药物可接受载体组合的组合物，以及与抑制需要温血动物的PDE10有关的使用方法。