[2-(3,4-Dichloroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-(3,4-Dichloroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
• 化学式: C₁₄H₁₁Cl₂NO₃S
• 分子量: 344.2
• InChiKey: BONNFOBMTFYBCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] METHODS RELATED TO ACTIVATION OF THE BONE MORPHOGENIC PROTEIN SIGNALING PATHWAY<br/>[FR] MÉTHODES LIÉES À L'ACTIVATION DE LA VOIE DE SIGNALISATION DES PROTÉINES MORPHOGÉNÉTIQUES OSSEUSES
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2019005563A1

  公开（公告）日：2019-01-03

  In one aspect, compounds and compositions that activate BMP signaling and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with diminished BMP signaling such as, for example, cancer, juvenile polyposis syndrome, hereditary pulmonary arterial hypertension, obesity osteosporosis, and chronic kidney disease. The disclosed compounds and compositions can also be useful in cartilage repair and bone formation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.