[4-[2-(2-Hydroxyethoxy)ethyl]piperazin-1-yl]-[4-(methylaminomethyl)phenyl]methanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-[2-(2-Hydroxyethoxy)ethyl]piperazin-1-yl]-[4-(methylaminomethyl)phenyl]methanone
• 英文别名: [4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-[4-(methylaminomethyl)phenyl]methanone
• 化学式: C₁₇H₂₇N₃O₃
• 分子量: 321.4
• InChiKey: PGBKHAVQAGPZBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  65
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：The UNIVERSITY OF TOKYO

  公开号：US20140227780A1

  公开（公告）日：2014-08-14

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, including separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) where R 1 to R 7 , W, X, Y, Z, Ar 1 and n are as defined in the description to differentiate them into megakaryocytes and/or platelets.