2-[2-(Fluoromethyl)phenyl]-1-(3-nitrophenyl)guanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(Fluoromethyl)phenyl]-1-(3-nitrophenyl)guanidine
• 英文别名: 2-[2-(fluoromethyl)phenyl]-1-(3-nitrophenyl)guanidine
• 化学式: C14H13FN4O2
• 分子量: 288.28
• InChiKey: SZQIZRPPXBFRKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  96.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Phenyl-Guanidine Derivatives
  申请人：Chemo Research, S.L

  公开号：US20140228388A1

  公开（公告）日：2014-08-14

  Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumours, as well as pharmaceutical compositions comprising them, their use in therapy and processes for their preparation.