5-N-benzhydryl-6-oxo-1H-pyrimidine-2,5-dicarboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-N-benzhydryl-6-oxo-1H-pyrimidine-2,5-dicarboxamide
• 化学式: C₁₉H₁₆N₄O₃
• 分子量: 348.4
• InChiKey: MWYUQYPCZVYZFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• SUBSTITUTED PYRIMIDINES
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20140235583A1

  公开（公告）日：2014-08-21

  The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

  本发明涉及取代嘧啶，用作HIF脯氨酸羟化酶抑制剂以治疗贫血和类似疾病。
• SUBSTITUTED PYRIMIDINES AS INHIBITORS OF HIF PROLYL HYDROXYLASE
  申请人：UJJAINWALLA FEZ

  公开号：US20170240513A1

  公开（公告）日：2017-08-24

  The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
• US9034851B2
  申请人：——

  公开号：US9034851B2

  公开（公告）日：2015-05-19