2-(2,3-Dibromophenyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,3-Dibromophenyl)benzamide
• 英文别名: 2-(2,3-dibromophenyl)benzamide
• 化学式: C₁₃H₉Br₂NO
• 分子量: 355.02
• InChiKey: DMMUAFMCZMCXOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• METHOD OF TREATING LYSOSOMAL STORAGE DISORDERS
  申请人：The Hospital for Sick Children

  公开号：US20140235713A1

  公开（公告）日：2014-08-21

  Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
• METHOD FOR ENHANCING FOLDING AND TRANSPORT OF MISFOLDED GLUCOCEREBROSIDASE
  申请人：The Hospital for Sick Children

  公开号：US20140249233A1

  公开（公告）日：2014-09-04

  Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
• [EN] HIGH DRUG LOADING LIQUID ORAL PHARMACEUTICAL COMPOSITIONS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES LIQUIDES À FORTE CHARGE POUR ADMINISTRATION PAR VOIE ORALE
  申请人：ZYWIE LLC

  公开号：WO2016154313A1

  公开（公告）日：2016-09-29

  A high drug loading liquid oral pharmaceutical composition comprises (i) an active pharmaceutical ingredient selected from the group consisting of a BCS Class 1 drag, a BCS Class II drug, a small molecule chaperone, and combinations thereof; (ii) at least one pharmaceutically acceptable excipient; and (iii) a diluent, wherein the active pharmaceutical ingredient is in the form, of granules having a granular core comprising from about 60 to about 97 weight percent of an active pharmaceutical ingredient and from about 3 to about 40 weight percent of the excipient, wherein the weight percent is based on the total weight of the granular core; wherein the granule core is coated with (iv) a water-soluble seal coating in an amount to provide from about 0.5 to about 5 percent weight gain, and (v) an enteric coating in an amount to provide from about 0.5 to about 50 percent weight gain. Unexpected advantages of the high drug loading oral suspension composition according to the invention include at least the following: (1) improved adsorption in the gastrointestinal tract; (2) maintain effective blood concentration over a 24 hour period; (3) reduce undesirable side effects of excipients as compared to solid dosage forms; (4) reduce the number of doses required; and (5) provide an improved taste and mouthfeel qualities.
• [EN] DUAL CHAMBER SYRINGE FOR MIXING AND DISPENSING ORAL LIQUID PHARMACEUTICAL DOSAGE FORMS DIRECTLY IN THE MOUTH OF A PATIENT<br/>[FR] SERINGUE À DOUBLE CHAMBRE POUR LE MÉLANGE ET LA DISTRIBUTION DE FORMES POSOLOGIQUES PHARMACEUTIQUES LIQUIDES À ADMINISTRATION ORALE DIRECTEMENT DANS LA BOUCHE D'UN PATIENT
  申请人：ZYWIE LLC

  公开号：WO2016160469A1

  公开（公告）日：2016-10-06

  A dual chamber syringe for mixing and dispensing an oral liquid pharmaceutical dosage form comprising: (a) a syringe housing having an outer wall and a proximal and distal end portions, wherein the syringe housing comprises an upper chamber comprising a liquid containing pouch and a lower chamber comprising a dry component, wherein the liquid containing pouch comprises a liquid component; (b) a piston positioned within the syringe housing and movable between the proximal and distal end portions of the syringe housing during use, wherein the piston provides an attachment means for securing the liquid containing pouch; (c) a flow aperture at the distal end of the syringe housing for receiving and dispensing the oral liquid pharmaceutical dosage, wherein the oral liquid pharmaceutical dosage form comprises the liquid component and the dry component; and (d) a puncture rod which is inserted into the syringe housing through the flow aperture to pierce the liquid containing pouch. Unexpected advantages of the dual chamber syringe for mixing and dispensing liquid oral pharmaceutical dosage forms include at least the following: (1) the dual chamber syringe is capable of storing two components which have to be mixed prior to use and does not affect the safety and quality of the oral liquid pharmaceutical dosage form; (2) the dual chamber syringe is able to store formulations which are not stable for storage for a long time; (3) the dual chamber syringe is simple and economical to manufacture and has a minimum number of parts to; and (4) the dual chamber syringe is easy to use, and may be discarded after use.