(2,5-Dioxopyrrolidin-1-yl) 3-(tert-butyldisulfanyl)propanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 3-(tert-butyldisulfanyl)propanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3-(tert-butyldisulfanyl)propanoate
• 化学式: C₁₁H₁₇NO₄S₂
• 分子量: 291.4
• InChiKey: SNCREPJKZFRFAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Reusable initiators for synthesizing nucleic acids
  申请人：Molecular Assemblies, Inc.

  公开号：US10683536B2

  公开（公告）日：2020-06-16

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.

  本发明提供了使用与固体支持物耦合的可再生引发剂合成多核苷酸（如 DNA 和 RNA）的改进方法。使用本发明的方法，可以在水环境中逐个碱基从头合成特定序列的多核苷酸，而无需使用核酸模板。
• Methods and apparatus for synthesizing nucleic acids
  申请人：Molecular Assemblies, Inc.

  公开号：EP2796552B1

  公开（公告）日：2016-07-13
• METHODS AND APPARATUS FOR SYNTHESIZING NUCLEIC ACIDS
  申请人：Molecular Assemblies, Inc.

  公开号：US20140363852A1

  公开（公告）日：2014-12-11

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template. Because the nucleotide analogs have an unmodified 3′ OH, i.e., as found in “natural” deoxyribose and ribose molecules, the analogs result in natural polynucleotides suitable for incorporation into biological systems.
• METHODS AND APPARATUS FOR SYNTHESIZING NUCLEIC ACID
  申请人：MOLECULAR ASSEMBLIES, INC.

  公开号：US20160046973A1

  公开（公告）日：2016-02-18

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template. Because the nucleotide analogs have an unmodified 3′ OH, i.e., as found in “natural” deoxyribose and ribose molecules, the analogs result in natural polynucleotides suitable for incorporation into biological systems.
• REUSABLE INITIATORS FOR SYNTHESIZING NUCLEIC ACIDS
  申请人：MOLECULAR ASSEMBLIES, INC.

  公开号：US20160046974A1

  公开（公告）日：2016-02-18

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.