(2-Oxo-2-pyrrolidin-1-ylethyl) 4-methylbenzoate | 380541-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Oxo-2-pyrrolidin-1-ylethyl) 4-methylbenzoate
• CAS: 380541-11-7
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.29
• InChiKey: KYQCIFYXLPHBLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] SMALL MOLECULE INHIBITORS OF DYRK1A AND USES THEREOF<br/>[FR] PETITES MOLÉCULES INHIBITRICES DE DYRK1A ET LEURS UTILISATIONS
  申请人：UNIV ARIZONA

  公开号：WO2017040993A1

  公开（公告）日：2017-03-09

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a benzimidazole or imidazopyridine structure which function as inhibitors of DYRK1A protein, and their use as therapeutics for the treatment of Alzheimer's disease, Down syndrome, glioblastoma, autoimmune diseases, inflammatory disorders (e.g., airway inflammation), and other diseases.