2-[3-[[amino-(N-methyl-3-methylsulfanylanilino)methylidene]amino]-4-chlorophenyl]sulfanylethyl ethanimidate

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[3-[[amino-(N-methyl-3-methylsulfanylanilino)methylidene]amino]-4-chlorophenyl]sulfanylethyl ethanimidate
• 化学式: C₁₉H₂₃ClN₄OS₂
• 分子量: 423.0
• InChiKey: YFCZORVTRBKXAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHOD FOR THE SYNTHESIS OF 18F-LABELLED BIOMOLECULES
  申请人：GE HEALTHCARE LIMITED

  公开号：US20140235861A1

  公开（公告）日：2014-08-21

  The present invention provides a method for the synthesis of 18 F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised.
• METHOD FOR THE SYNTHESIS OF 18F-LABELLED MOLECULES
  申请人：GE HEALTHCARE LIMITED

  公开号：US20140243555A1

  公开（公告）日：2014-08-28

  The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised.
• US9085518B2
  申请人：——

  公开号：US9085518B2

  公开（公告）日：2015-07-21
• US9125954B2
  申请人：——

  公开号：US9125954B2

  公开（公告）日：2015-09-08