N-[(E)-(2-cyanophenyl)methyleneamino]pyridine-4-carboxamide | 1042157-27-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[(E)-(2-cyanophenyl)methyleneamino]pyridine-4-carboxamide
• 英文别名: N-[(E)-(2-cyanophenyl)methylideneamino]pyridine-4-carboxamide
• CAS: 1042157-27-6
• 化学式: C₁₄H₁₀N₄O
• 分子量: 250.26
• InChiKey: CRZNGFOOQVQWRG-LICLKQGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异烟肼 、 2-氰基苯甲醛 以 乙醇 、 水 为溶剂， 以70%的产率得到N-[(E)-(2-cyanophenyl)methyleneamino]pyridine-4-carboxamide
  参考文献：
  名称：

  Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives

  摘要：

  A series of 22 (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37RV using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in mu g/mL. Compounds 2f, 2g, 2j, 2k and 2q exhibited a significant activity (0.31-0.62 mu g/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.08.003

文献信息

• Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives
  作者：Maria Cristina da Silva Lourenço、Marcelle de Lima Ferreira、Marcus Vinícius Nora de Souza、Mônica Amado Peralta、Thatyana Rocha Alves Vasconcelos、Maria das Graças M.O. Henriques

  DOI：10.1016/j.ejmech.2007.08.003

  日期：2008.6

  A series of 22 (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37RV using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in mu g/mL. Compounds 2f, 2g, 2j, 2k and 2q exhibited a significant activity (0.31-0.62 mu g/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis. (c) 2007 Elsevier Masson SAS. All rights reserved.