2-N-(4-chlorophenyl)-2-N-(4-fluorophenyl)pyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-N-(4-chlorophenyl)-2-N-(4-fluorophenyl)pyrimidine-2,4-diamine
• 化学式: C₁₆H₁₂ClFN₄
• 分子量: 314.74
• InChiKey: RSOOVPIEFBBWMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO<br/>[FR] COMPOSITIONS FAVORISANT TGF-BÊTA POUR LA RÉPARATION DU CARTILAGE ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV EMORY

  公开号：WO2014130411A1

  公开（公告）日：2014-08-28

  This disclosure relates to compounds and compositions for cartilage repair and methods related thereto. In certain embodiments, the disclosure relates to methods of inducing cartilage growth and regeneration comprising administering an effective amount of a composition comprising a compound disclosed herein to the subject or implanting a cartilage matrix comprising a compound disclosed herein in the subject. In certain embodiments, the compound is used locally such as injection at any desired site of cartilage formation.