4-(Difluoromethyl)-1,2-dimethylpyrrolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-(Difluoromethyl)-1,2-dimethylpyrrolidine
• 英文别名: 4-(difluoromethyl)-1,2-dimethylpyrrolidine
• 化学式: C₇H₁₃F₂N
• 分子量: 149.18
• InChiKey: ODDVNWZGPZEWMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS<br/>[FR] COMPOSÉS ET MÉTHODES POUR LE TRAITEMENT DE LA MUCOVISCIDOSE
  申请人：FLATLEY DISCOVERY LAB LLC

  公开号：WO2017117239A1

  公开（公告）日：2017-07-06

  The invention relates to a compound of Formula (I) or (IA) compositions comprising compounds of Formula (I) or (IA), and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula (I) or (IA) to a patient in need thereof:

  该发明涉及公式（I）或（IA）的化合物，包括化合物的组合物公式（I）或（IA），以及治疗囊性纤维化的方法，包括向需要的患者施用公式（I）或（IA）的化合物的治疗有效量的步骤。
• COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
  申请人：Flatley Discovery Lab, LLC

  公开号：US20170204110A1

  公开（公告）日：2017-07-20

  The invention relates to a compound of Formula I or IA compositions comprising compounds of Formula I or IA, and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
• US8815928B2
  申请人：——

  公开号：US8815928B2

  公开（公告）日：2014-08-26
• [EN] COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS<br/>[FR] COMPOSÉS ET MÉTHODES POUR LE TRAITEMENT DE LA FIBROSE KYSTIQUE
  申请人：FLATLEY DISCOVERY LAB LLC

  公开号：WO2020160010A1

  公开（公告）日：2020-08-06

  The invention relates to a compound of Formula I, pharmaceutical compositions comprising a compound of Formula I, and pharmaceutically acceptable slats thereof, pharmaceutical compositions comprising such compounds and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I to a subject in need thereof.