[1-[3-[4-[[3-[3-[[(4R)-4-(8-hydroxy-2-oxo-1H-quinolin-5-yl)pyrrolidin-2-yl]methyl]phenyl]propanoylamino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1-[3-[4-[[3-[3-[[(4R)-4-(8-hydroxy-2-oxo-1H-quinolin-5-yl)pyrrolidin-2-yl]methyl]phenyl]propanoylamino]methyl]-N-methylanilino]-3-oxopropyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate
• 化学式: C₅₂H₅₆N₆O₆
• 分子量: 861.0
• InChiKey: CRMGWGBDOJKLOV-KLBOFATRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  64
• 可旋转键数：
  16
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  152
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Diamide Compounds Having Muscarinic Receptor Antagonist and Beta2 Adrenergic Receptor Agonist Activity
  申请人：Theravance Respiratory Company, LLC

  公开号：US20170362200A1

  公开（公告）日：2017-12-21

  This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor antagonist and β 2 adrenergic receptor agonist activities. The invention also relates to pharmaceutical compositions comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compounds as bronchodilating agents to treat pulmonary disorders.
• US8816088B2
  申请人：——

  公开号：US8816088B2

  公开（公告）日：2014-08-26