N-(2-aminoethyl)-1,14,39,40,41,42,43,44-octazaoctacyclo[12.12.12.13,7.18,12.116,20.121,25.128,32.133,37]tetratetraconta-3(44),4,6,8,10,12(43),16(42),17,19,21,23,25(41),28(40),29,31,33,35,37(39)-octadecaene-5-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(2-aminoethyl)-1,14,39,40,41,42,43,44-octazaoctacyclo[12.12.12.13,7.18,12.116,20.121,25.128,32.133,37]tetratetraconta-3(44),4,6,8,10,12(43),16(42),17,19,21,23,25(41),28(40),29,31,33,35,37(39)-octadecaene-5-carboxamide
• 化学式: C₃₉H₃₆N₁₀O
• 分子量: 660.8
• InChiKey: JIMVHNTZPONXKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  50
• 可旋转键数：
  3
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• METHOD FOR DETECTING AND/OR QUANTIFYING AN ANALYTE AT THE SURFACE OF A CELL
  申请人：Bazin Hervé

  公开号：US20140242611A1

  公开（公告）日：2014-08-28

  The invention relates to a method for quantifying a protein of interest expressed at the surface of a cell or else present in a tissue sample, said method comprising the use of two ligands capable of binding specifically to a domain of said protein.
• METHOD FOR DETERMINING THE ABILITY OF AN ANTIBODY TO KEEP CELLS CLOSE TO ONE ANOTHER
  申请人：CISBIO BIOASSAYS

  公开号：US20150045253A1

  公开（公告）日：2015-02-12

  The invention relates to a method for determining the ability of a candidate antibody to keep a first cell and a second cell close to one another, said method comprising the following steps: bringing said candidate antibody in contact with (i) a first cell expressing, in the extracellular portion of its plasma membrane, a first protein that is known to be or is suspected of being recognized by the candidate antibody and (ii) a second cell expressing, in the extracellular portion of the plasma membrane, a second protein that is also known to be or suspected of being recognized by the candidate antibody, each of the proteins being labeled with a member of a pair of FRET partners, and measurement of the FRET signal and comparison with the signal measured in the absence of the candidate antibody. The invention also relates to a reagent kit for carrying out this method.
• METHOD FOR DETERMINING THE GLYCOSYLATION OF AN ANTIBODY
  申请人：Jaga Delphine

  公开号：US20150024410A1

  公开（公告）日：2015-01-22

  The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out these methods.
• METHOD FOR NORMALIZING THE LUMINESCENCE EMITTED BY A MEASURING MEDIUM
  申请人：Mathis Gerard

  公开号：US20150185150A1

  公开（公告）日：2015-07-02

  The subject matter of the invention is a method for measuring the luminescence of a long-life fluorescent compound present in a measuring medium, said medium containing a biological sample, characterized in that it comprises the following steps: a) introduction of a long-life fluorescent compound into the measuring medium, b) introduction, into the measuring medium, of a fluorescent marking agent, the absorption spectrum of which allows the excitation thereof at the same wavelength as that used to excite the long-life fluorescent compound, wherein said emission spectrum allows the measurement of the luminescence thereof at the same wavelength as that used to measure the luminescence of the long-life fluorescent compound, c) excitation of the measuring medium with a wavelength corresponding to an absorption peak of the long-life fluorescent compound, d) measurement of the luminescence emitted by the measuring medium immediately after excitation of said medium, mainly corresponding to the luminescence of the marking agent, and for a period of 5 ns to 45 μs, at a wavelength correspondant to an emission peak of the long-life fluorescent compound, e) time-resolved measurement of the luminescence emitted by the measuring medium at the same wavelength as that used in step d), after a delay of 20 to 200 μs following the excitation of the measuring medium and for a period of 200 to 1000 μs, this luminescence mainly corresponding to that of the long-life fluorescent compound, f) calculation of a normalized luminescence signal corresponding to the ratio: (signal obtained in step e)/(signal obtained in step d).
• THERANOSTIC METHOD BASED ON THE DETECTION OF HER2-HER2 DIMERS
  申请人：CISBIO BIOASSAYS

  公开号：US20150198602A1

  公开（公告）日：2015-07-16

  The present invention relates to an ex vivo method for determining the susceptibility of a patient suffering from cancer to respond to a therapeutic treatment based on the administration of an antibody specific for the HER2 protein, this method comprising the quantification of HER2-HER2 dimers in a tissue sample from said patient using the FRET technique. The invention also relates to a kit of reagents for implementing this method.